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T淋巴细胞表型对慢性HBV感染免疫状态的影响及应用价值

赵金花 李俊峰 毛小荣

赵金花, 李俊峰, 毛小荣. T淋巴细胞表型对慢性HBV感染免疫状态的影响及应用价值[J]. 临床肝胆病杂志, 2020, 36(5): 1019-1023. DOI: 10.3969/j.issn.1001-5256.2020.05.014.
引用本文: 赵金花, 李俊峰, 毛小荣. T淋巴细胞表型对慢性HBV感染免疫状态的影响及应用价值[J]. 临床肝胆病杂志, 2020, 36(5): 1019-1023. DOI: 10.3969/j.issn.1001-5256.2020.05.014.
Zhao JinHua, Li JunFeng, Mao XiaoRong. Effect of T-lymphocyte phenotype on immune status in chronic hepatitis B virus infection and its application value[J]. J Clin Hepatol, 2020, 36(5): 1019-1023. DOI: 10.3969/j.issn.1001-5256.2020.05.014.
Citation: Zhao JinHua, Li JunFeng, Mao XiaoRong. Effect of T-lymphocyte phenotype on immune status in chronic hepatitis B virus infection and its application value[J]. J Clin Hepatol, 2020, 36(5): 1019-1023. DOI: 10.3969/j.issn.1001-5256.2020.05.014.

T淋巴细胞表型对慢性HBV感染免疫状态的影响及应用价值

DOI: 10.3969/j.issn.1001-5256.2020.05.014
基金项目: 

国家自然科学基金项目(81800528); 甘肃省卫生行业科研计划项目(GSWSKY2018-24); 兰州大学第一医院院内基金(ldyyyn2017-17); 兰州市城关区科研专项(2018SHFZ0023); 

详细信息
  • 中图分类号: R512.62

Effect of T-lymphocyte phenotype on immune status in chronic hepatitis B virus infection and its application value

Research funding: 

 

  • 摘要:

    目的探讨T淋巴细胞表型与慢性乙型肝炎免疫状态的关系及其应用价值。方法纳入2015年1月-2019年5月就诊于兰州大学第一医院的慢性乙型肝炎患者77例,依据HBeAg状态、血清中ALT、HBsAg和HBV DNA水平将其分为免疫耐受期和非免疫耐受期。获取患者T淋巴细胞表型、HBV血清学指标、HBV DNA载量、血常规及肝功能等主要实验室检查指标并计算APRI及FIB-4。符合正态性分布的计量资料2组间比较采用t检验;不符合正态性分布的计量资料2组间比较采用Mann-WhitneyU检验;计数资料组间比较采用χ2检验。两变量间相关效应检验采用Spearman相关分析。采用受试者工作特征曲线下面积(AUC)评价Treg、CD8+PD-1+T淋巴细胞百分比和CD8+CD45RO+T淋巴细胞百分比诊断效能。结果 Treg和CD8+PD-1+百分比在免疫耐受期明显高于非免疫耐受期(U值分别为12. 0、59. 0,P值分别为<0001、0....

     

  • [1] GEHRING AJ, PROTZER U. Targeting innate and adaptive immune responses to cure chronic HBV infection[J]. Gastroenterology, 2019, 156(2):325-337.
    [2] PROTZER U, MAINI MK, KNOLLE PA. Living in the liver:Hepatic infections[J]. Nat Rev Immunol, 2012, 12(3):201-213.
    [3] MUELLER SN, AHMED R. High antigen levels are the cause of T cell exhaustion during chronic viral infection[J]. Proc Natl Acad Sci U S A, 2009, 106(21):8623-8628.
    [4] UTZSCHNEIDER DT, ALFEI F, ROELLI P, et al. High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival[J]. J Exp Med, 2016, 213(9):1819-1834.
    [5] KENNEDY P, SANDALOVA E, JO J, et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B[J]. Gastroenterology, 2012, 143(3):637-645.
    [6] Chinese Society of Infectious Diseases, Chinese Medical Association; Chinese Society of Hepatology, Chinese Medical Association. Guidelines for the prevention and treatment of chronic hepatitis B(version 2019)[J]. J Clin Hepatol, 2019,35(12):2648-2669.(in Chinese)中华医学会感染病学分会,中华医学会肝病学分会.慢性乙型肝炎防治指南(2019年版)[J].临床肝胆病杂志,2019, 35(12):2648-2669.
    [7] LANG J, NEUMANN-HAEFELIN C, THIMME R. Immunological cure of HBV infection[J]. Hepatol Int, 2019, 13(2):113-124.
    [8] RAO PE, PETRONE AL, PONATH PD. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}[J]. J Immunol, 2005, 174(3):1446-1455.
    [9] WANG X, DONG Q, LI Q, et al. Dysregulated response of follicular helper T cells to hepatitis B surface antigen promotes HBV persistence in mice and associates with outcomes of patients[J]. Gastroenterology, 2018, 154(8):2222-2236.
    [10] ASABE S, WIELAND SF, CHATTOPADHYAY PK, et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection[J]. J Virol, 2009, 83(19):9652-9662.
    [11] THIMME R, WIELAND S, STEIGER C, et al. CD8(+)T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection[J]. J Virol, 2003, 77(1):68-76.
    [12] XIE DY, CHEN FJ, LIN BL, et al. The expressions of PD-1and PD-L1 and the correlation with the degree of liver damage in HBV chronic infection[J/CD]. Chin J Exp Clin Infect Dis(Electronic Version), 2010, 4(3):31-34.(in Chinese)谢冬英,陈凤娟,林炳亮,等.PD-1和PD-L1表达与慢性HBV感染者肝脏病变程度的相关性[J/CD].中华实验和临床感染病杂志(电子版),2010, 4(3):31-34.
    [13] ZHAO HZ, QI QG, LIU RJ, et al. The relationship among programmed death receptor 1 expression of peripheral blood T lymphocytes, hepatitis B virus DNA load and alanine aminotransferase level in chronic hepatitis B patients under different immune status[J/CD]. Chin J Exp Clin Infect Dis(Electronic Edition), 2018,12(6):585-589.(in Chinese)赵海珍,其其格,刘瑞军,等.慢性乙型肝炎患者不同免疫状态下外周血T淋巴细胞程序性死亡受体1表达与乙型肝炎病毒DNA载量及丙氨酸氨基转移酶水平的相关性[J/CD].中华实验和临床感染病杂志(电子版),2018,12(6):585-589.
    [14] HOOGEVEEN RC, ROBIDOUX MP, SCHWARZ T, et al. Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection[J].Gut, 2019, 68(5):893-904.
    [15] KAH J, KOH S, VOLZ T, et al. Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection[J]. J Clin Invest, 2017, 127(8):3177-3188.
    [16] PALEY MA, KROY DC, ODORIZZI PM, et al. Progenitor and terminal subsets of CD8+T cells cooperate to contain chronic viral infection[J]. Science, 2012, 338(6111):1220-1225.
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  • 收稿日期:  2019-12-16
  • 出版日期:  2020-05-20
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