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GP模型对ALT小于2倍正常值上限的慢性HBV感染者肝纤维化的诊断价值

张杰灵 邹桂舟 郜玉峰 李家斌

文夏杰, 李桂馨, 李婕, 等. 合并非酒精性脂肪性肝病的慢性乙型肝炎患者HBV复制与脂代谢的相互影响[J]. 临床肝胆病杂志, 2021, 37(7): 1495-1500. DOI: 10.3969/j.issn.1001-5256.2021.07.002.
引用本文: 文夏杰, 李桂馨, 李婕, 等. 合并非酒精性脂肪性肝病的慢性乙型肝炎患者HBV复制与脂代谢的相互影响[J]. 临床肝胆病杂志, 2021, 37(7): 1495-1500. DOI: 10.3969/j.issn.1001-5256.2021.07.002.
WEN XJ, LI GX, LI J, et al. Interaction between hepatitis B virus replication and lipid metabolism in patients with chronic hepatitis B and NAFLD[J]. J Clin Hepatol, 2021, 37(7): 1495-1500. DOI: 10.3969/j.issn.1001-5256.2021.07.002.
Citation: WEN XJ, LI GX, LI J, et al. Interaction between hepatitis B virus replication and lipid metabolism in patients with chronic hepatitis B and NAFLD[J]. J Clin Hepatol, 2021, 37(7): 1495-1500. DOI: 10.3969/j.issn.1001-5256.2021.07.002.

GP模型对ALT小于2倍正常值上限的慢性HBV感染者肝纤维化的诊断价值

DOI: 10.3969/j.issn.1001-5256.2020.05.016
基金项目: 

安徽省中央引导地方科技发展项目(201907d07050008); 合肥市借转补基金项目(J2019Y04); 

详细信息
  • 中图分类号: R512.62;R575.2

Value of globulin-platelet model in diagnosis of liver fibrosis in patients with chronic hepatitis B virus infection and alanine aminotransferase <2 ×upper limit of normal

Research funding: 

 

  • 摘要:

    目的探讨GP模型对ALT <2倍正常值上限(ULN)的慢性HBV感染者肝纤维化程度的诊断价值。方法回顾性分析2010年1月-2018年12月在安徽医科大学第二附属医院接受肝穿刺活组织检查且ALT <2×ULN的659例慢性HBV感染患者的临床资料。根据肝穿刺病理将患者的肝纤维化程度分为显著肝纤维化(≥S2)、严重肝纤维化(≥S3)和肝硬化(S4),通过患者球蛋白(Glb)、PLT计算GP模型值,应用受试者工作特征曲线(ROC曲线)评估GP模型诊断肝纤维化程度的临床价值,并与经典的APRI评分和FIB-4指数比较。计量资料符合正态分布的多组间比较采用方差分析,不符合正态分布的多组间比较采用KruskalWallisH秩和检验;计数资料多组间比较采用χ2检验。采用Spearman相关分析评估无创模型与肝纤维化分期的相关性。结果 GP模型值在不同肝纤维化程度的患者间差异显著(χ2=126. 960,P<0. 001)。随着肝纤维化程度的加重,GP模型值逐渐升高,GP模型与肝纤维化程度呈显著正相关(r=0.401,P<0. 0...

     

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    6. 倪盟,曾雷. miRNA单核苷酸多态性与HBV感染相关疾病关系的研究进展. 吉林大学学报(医学版). 2021(06): 1588-1593 . 百度学术

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  • 收稿日期:  2019-10-24
  • 出版日期:  2020-05-20
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