同型半胱氨酸在肝纤维化和肝硬化发展中的作用

王亚刚; 胡国信

doi:10.3969/j.issn.1001-5256.2020.05.044

同型半胱氨酸在肝纤维化和肝硬化发展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.05.044

1. 广州医科大学
2. 北京大学深圳医院感染病科
3. 深圳市福田区慢性病防治院

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2020-05-20

Mechanism of action of homocysteine in the development of liver fibrosis and liver cirrhosis

Guangzhou Medical University, Guangzhou 510006, China

摘要

摘要:
同型半胱氨酸(Hcy)因被发现与心脑血管病、高血压、糖尿病、肾脏病变、骨骼系统疾病甚至精神疾病具有明显相关性而被医学界所关注。近年来,Hcy在肝纤维化、肝硬化中的应用也越来越被临床医生及研究者所重视。综述了近年来国内外有关Hcy的代谢机制、生理病理意义,并着重阐述了Hcy和肝纤维化、肝硬化的相关性和可能机制。
- 高半胱氨酸 /
- 肝硬化 /
- 高血糖症 /
- 氧化应激
Abstract:
Homocysteine(Hcy) has attracted more and more attention in the medical field since it was found to be closely associated with cardiovascular and cerebrovascular diseases, hypertension, diabetes, kidney diseases, skeletal system diseases, and even mental illnesses.In recent years, the application of Hcy in patients with liver fibrosis and liver cirrhosis has been taken more seriously by clinicians and researchers. This article reviews the recent research advances in the metabolic mechanism and pathophysiologic significance of Hcy in China and foreign countries and highlights the association of Hcy with liver fibrosis and liver cirrhosis and its possible mechanism.
- homocysteine /
- liver fibrosis /
- hyperglycemia /
- oxidative stress

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参考文献(34)

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