核受体在原发性胆汁性胆管炎发生发展中的作用

余海燕; 唐映梅

doi:10.3969/j.issn.1001-5256.2020.05.049

核受体在原发性胆汁性胆管炎发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.05.049

昆明医科大学第二附属医院消化内科

基金项目:

国家自然科学基金项目（81660102）；昆明医科大学研究生创新基金项目（2019S039）；云南省自然科学基金项目（2018FE001）；云南省卫生科技计划项目（2017NS280）；

详细信息

中图分类号: R575.7
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出版历程
- 出版日期: 2020-05-20

Role of nuclear receptor in the development and progression of primary biliary cholangitis

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China

Research funding:

摘要

摘要:
原发性胆汁性胆管炎(PBC)是一种原因不明的慢性进行性肝内胆汁淤积性自身免疫性肝病。目前PBC的病因和发病机制尚不完全清楚。核受体是配体依赖性转录因子超家族,通过信号分子与转录应答间构建联系,调控细胞的生长和分化。人类中核受体家族包含48个成员,如过氧化物酶体增殖物激活受体、孕烷X受体、组成型雄烷受体、肝X受体、法尼醇X受体、维生素D受体、糖皮质激素受体等,受到广泛关注。这些核受体在转录水平调节胆汁酸代谢的关键酶和转运体基因,从而调节体内胆汁酸水平及参与炎症反应。而胆汁酸代谢紊乱和炎症的持续可能是PBC发生发展的关键因素。就核受体在PBC发生发展中的研究进展作一综述,为PBC的发病机制和寻找新的治疗靶点提供理论基础。
- 肝硬化,胆汁性 /
- 受体,胞质和核 /
- 调节元件,转录
Abstract:
Primary biliary cholangitis(PBC) is an chronic progressive intrahepatic cholestasis autoimmune liver disease with unknown causes, and at present, the etiology and pathogenesis of PBC remain unclear. Nuclear receptor is a ligand-dependent transcription factor superfamily that regulates cell growth and differentiation by establishing a relationship between signal molecules and transcriptional responses.The human nuclear receptor family consists of 48 members, including peroxisome proliferator-activated receptors, pregnane X receptor,constitutive androstane receptor, liver X receptors, farnesoid X receptor, vitamin D receptor, and glucocorticoid receptor, which have attracted wide attention. These nuclear receptors regulate the key enzymes and transporter genes of bile acid metabolism at the transcriptional level and thus regulate the level of bile acid in the body and participate in inflammatory response. Bile acid metabolism disorder and persistent inflammation may be the key factors for the development and progression of PBC. This article reviews the research advances in nuclear receptors in the development and progression of PBC, in order to provide a theoretical basis for exploring the pathogenesis of PBC and new therapeutic targets.
- liver cirrhosis,biliary /
- receptors,cytoplasmic and nuclear /
- regulatory elements,transcriptional

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