中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝细胞癌微血管侵犯定义和病理分级标准

何旭昶 安文慧 赵海泉 沈辉 杨婧 莫小华

引用本文:
Citation:

肝细胞癌微血管侵犯定义和病理分级标准

DOI: 10.3969/j.issn.1001-5256.2020.05.052
基金项目: 

科技人才和平台计划项目(2019IC034); 

详细信息
  • 中图分类号: R735.7

Microvascular invasion in hepatocellular carcinoma:Definition and criteria for pathological grading

Research funding: 

 

  • 摘要:

    肝细胞癌的预后与微血管侵犯(MVI)密切相关,近年来对于MVI的临床研究越来越多,但对于基础病理发展与争议的文献则较少。作为临床研究的基础,了解微血管侵犯的定义及病理分级的争议具有重要意义。旨在对MVI定义的发展历程进行回顾,复习现有文献,并对MVI病理分级标准的研究现状进行分析,探讨不同分级标准对于肝细胞癌术后复发的预测价值,为MVI的临床研究提供参考。

     

  • [1] BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6):394-424.
    [2] CHEN W, ZHENG R, BAADE PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin 2016, 66(2):115-132.
    [3] POON RT, FAN ST, TSANG FH, et al. Locoregional therapies for hepatocellular carcinoma:A critical review from the surgeon’s perspective[J]. Ann Surg, 2002, 235(4):466-486.
    [4] van NAGELL JR Jr, DONALDSON ES, WOOD EG, et al. The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer[J]. Cancer, 1978, 41(1):228-234.
    [5] BATSAKIS JG. Invasion of the microcirculation in head and neck cancer[J]. Ann Otol Rhinol Laryngol, 1984, 93(6 Pt1):646-647.
    [6] CLOSE LG, BURNS DK, REISCH J, et al. Microvascular invasion in cancer of the oral cavity and oropharynx[J]. Arch Otolaryngol Head Neck Surg, 1987, 113(11):1191-1195.
    [7] MAZZAFERRO V, REGALIA E, DOCI R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis[J]. N Engl J Med, 1996, 334(11):693-699.
    [8] COSTENTIN CE, BABABEKOV YJ, ZHU AX, et al. Is it time to reconsider the Milan criteria for selecting patients with hepatocellular carcinoma for deceased-donor liver transplantation?[J]. Hepatology, 2019, 69(3):1324-1336.
    [9] IWATSUKI S, DVORCHIK I, MARSH JW, et al. Liver transplantation for hepatocellular carcinoma:A proposal of a prognostic scoring system[J]. J Am Coll Surg, 2000, 191(4):389-394.
    [10] ESNAOLA NF, LAUWERS GY, MIRZA NQ, et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation[J].J Gastrointest Surg, 2002, 6(2):224-232; discussion 232.
    [11] SUMIE S, KUROMATSU R, OKUDA K, et al. Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors[J]. Ann Surg Oncol,2008, 15(5):1375-1382.
    [12] RODRÍGUEZ-PERÁLVAREZ M, LUONG TV, ANDREANA L,et al. A systematic review of microvascular invasion in hepatocellular carcinoma:Diagnostic and prognostic variability[J].Ann Surg Oncol, 2013, 20(1):325-339.
    [13] ROAYAIE S, BLUME IN, THUNG SN, et al. A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma[J]. Gastroenterology, 2009, 137(3):850-855.
    [14] ERSTAD DJ, TANABE KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma[J]. Ann Surg Oncol, 2019, 26(5):1474-1493.
    [15] Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group,Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association, et al. Evidencebased practice guidelines for the standardized pathological diagnosis of primary liver cancer in China(2015 update)[J]. J Clin Hepatol, 2015, 31(6):833-839.(in Chinese)中国抗癌协会肝癌专业委员会,中华医学会肝病学分会肝癌学组,中国抗癌协会病理专业委员会,等.原发性肝癌规范化病理诊断指南(2015年版)[J].临床肝胆病杂志,2015, 31(6):833-839.
    [16] National Health and Family Planning Commission of the People’s Republic of China. Diagnosis, management, and treatment of hepatocellular carcinoma[J]. J Clin Hepatol, 2017(8):1419-1431.(in Chinese)中华人民共和国国家卫生和计划生育委员会.原发性肝癌诊疗规范(2017年版)[J].临床肝胆病杂志,2017(8):1419-1431.
    [17] China Association for the Promotion of International Medical and Health Care Exchanges, Liver Cancer Branch. Expert consensus on HCC with vascular invasion(discussion draft)[J/CD]. Electronic J Liver Tumor, 2015, 2(3):8-18.(in Chinese)中国医疗保健国际交流促进会肝脏肿瘤分会.肝细胞癌合并血管侵犯专家共识(讨论稿)[J/CD].肝癌电子杂志,2015, 2(3):8-18.
    [18] WANG J, MA JL. Prognostic factors of liver cancer[J]. Chin J Gen Surg, 2015, 24(2):270-274.(in Chinese)汪晋,马金良.肝癌预后相关影响因素[J].中国普通外科杂志,2015, 24(2):270-274.
    [19] ZHANG XJ, LIU J, LIU K, et al. Effect of microvascular invasion on prognosis of patients with hepatocellular carcinoma after hepatectomy[J]. Chin J Dig Surg, 2018, 17(5):483-487.(in Chinese)张小晶,刘静,刘坤,等.微血管侵犯对肝癌肝切除术后预后的影响[J].中华消化外科杂志,2018, 17(5):483-487.
    [20] SHAH SA, TAN JC, MCGILVRAY ID, et al. Does microvascular invasion affect outcomes after liver transplantation for HCC?A histopathological analysis of 155 consecutive explants[J]. J Gastrointest Surg, 2007, 11(4):464-471.
    [21] SALA M, FUSTER J, LLOVET JM, et al. High pathological risk of recurrence after surgical resection for hepatocellular carcinoma:An indica tion for salvage liver transplantation[J]. Liver Transpl, 2004, 10(10):1294-1300.
    [22] YAMAMOTO Y, IKOMA H, MORIMURA R, et al. Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis[J]. World J Gastroenterol,2015, 21(1):246-253.
    [23] IGUCHI T, SHIRABE K, AISHIMA S, et al. New pathologic stratification of microvascular invasion in hepatocellular carcinoma:Predicting prognosis after living-donor liver transplantation[J]. Transplantation, 2015, 99(6):1236-1242.
    [24] SUMIE S, NAKASHIMA O, OKUDA K, et al. The significance of classifying microvascular invasion in patients with hepatocellular carcinoma[J]. Ann Surg Oncol, 2014, 21(3):1002-1009.
    [25] ZHAO H, CHEN C, FU X, et al. Prognostic value of a novel risk classification of microvascular invasion in patients with hepatocell ular carcinoma after resection[J]. Oncotarget,2017, 8(3):5474-5486.
    [26] ZHANG XJ, WANG L. Clinical significance of microvascular invasion in the comprehensive diagnosis and treatment of hepatocellular carcinoma[J]. Chin J Dig Surg, 2019, 18(4):336-341.(in Chinese)张小晶,王琳.微血管侵犯在肝癌综合诊断与治疗中的临床意义[J].中华消化外科杂志,2019, 18(4):336-341.
    [27] FENG LH, DONG H, LAU WY, et al. Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma[J]. J Cancer Res Clin Oncol, 2017, 143(2):293-303.
    [28] ZHANG X, LI J, SHEN F, et al. Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma[J]. J Gastroenterol Hepatol, 2018, 33(2):347-354.
    [29] ERSTAD DJ, TANABE KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma[J]. Ann Surg Oncol, 2019, 26(5):1474-149327.
    [30] CHICHE L, MENAHEM B, BAZILLE C, et al. Recurrence of hepatocellular carcinoma in noncirrhotic liver after hepatectomy[J]. World J Surg, 2013, 37(10):2410-2418.
    [31] LIM C, MISE Y, SAKAMOTO Y, et al. Above 5 cm, size does not matter anymore in patients with hepatocellular carcinoma[J]. World J Surg, 2014, 38(11):2910-2918.
    [32] OKUSAKA T, OKADA S, UENO H, et al. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features[J]. Cancer, 2002, 95(9):1931-1937.
  • 加载中
计量
  • 文章访问数:  2709
  • HTML全文浏览量:  140
  • PDF下载量:  289
  • 被引次数: 0
出版历程
  • 出版日期:  2020-05-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回