SARS、MERS和COVID-19感染所致肝损伤的临床特征及机制

龚航; 黄忠; 刘先丽

doi:10.3969/j.issn.1001-5256.2020.08.046

SARS、MERS和COVID-19感染所致肝损伤的临床特征及机制

DOI: 10.3969/j.issn.1001-5256.2020.08.046

1. 自贡市第一人民医院消化内科
2. 自贡市中医医院超声科

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2020-08-20

Clinical features and pathogenesis of liver injury caused by SARS,MERS and COVID-19

Department of Gastroenterology, The First People’s Hospital of Zigong

摘要

摘要:
2019新型冠状病毒导致的新型冠状病毒疾病已对全球公共卫生安全构成严重威胁。严重病例除了肺部疾病外伴有不同程度的肝损伤。以往研究表明,急性呼吸系统综合征冠状病毒和中东呼吸综合征冠状病毒感染者也可出现常见的肝损伤,且与疾病严重程度密切相关。主要从三大高致病性人类冠状病毒入手,分别阐述相关肝损伤的临床特点和机制,以供临床医生更清楚地认识该类病毒及作出更准确的决策。
- 冠状病毒属 /
- 肝损伤 /
- 肽基二肽酶A
Abstract:
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has become a serious threat to global public health security.Besides lung diseases,severe cases are also accompanied by varying degrees of liver injury.Previous studies have shown that patients infected with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus may also suffer from liver injury,which is closely associated with disease severity.This article elaborates on the clinical features and pathogenesis of liver injury caused by these three types of highly pathogenic human coronavirus,in order to help clinicians better understand this disease and make accurate decisions.
- coronavirus /
- liver injury /
- peptidyl-dipeptidase A

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参考文献(28)

[1] SU S,WONG G,SHI W,et al. Epidemiology,genetic recombination,and pathogenesis of coronaviruses[J]. Trends Microbiol,2016,24(6):490-502.

[2] ZHU N,ZHANG DY,WANG WL,et al. A novel coronavirus from patients with pneumonia in China,2019[J]. N Engl J Med,2020,382(8):727-733.

[3] XU L,LIU J,LU M,et al. Liver injury during highly pathogenic human coronavirus infections[J]. Liver Int,2020,40(5):998-1004.

[4] MAHALLAWI WH,KHABOUR OF,ZHANG Q,et al. MERS-Co V infection in humans is associated with a pro-inflammatory Th1and Th17 cytokine profile[J]. Cytokine,2018,104:8-13.

[5] ZHOU P,YANG XL,WANG XG,et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J].Nature,2020,579(7798):270-273.

[6] LI W,MOORE MJ,VASILIEVA N,et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus[J]. Nature,2003,426(6965):450-454.

[7] BANALES JM,HUEBERT RC,KARLSEN T,et al. Cholangiocyte pathobiology[J]. Nat Rev Gastroenterol Hepatol,2019,16(5):269-281.

[8] LAI SJ,CUI HL,CHEN DF,et al. Liver injury in coronavirus disease 2019[J]. J Clin Hepatol,2020,36(5):1004-1007.(in Chinese)赖姝婕，崔红利，陈东风，等．新型冠状病毒肺炎的肝损伤[J]．临床肝胆病杂志，2020,36(5):1004-1007.

[9] TAN YJ,FIELDING BC,GOH PY,et al. Overexpression of 7a,a protein specifically encoded by the severe acute respiratory syndrome coronavirus,induces apoptosis via a caspase-dependent pathway[J]. J Virol,2004,78(24):14043-14047.

[10] ZHAO G,JIANG Y,QIU H,et al. Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with middle east respiratory syndrome-coronavirus[J]. PLo S One,2015,10(12):e0145561.

[11] YU YC,LAI RT,CHEN CW. Key points and interpretation of EASL clinical practice guidelines:Drug-induced liver injury(2019)[J]. J Clin Hepatol,2019,35(6):1242-1250.(in Chinese)于乐成，赖荣陶，陈成伟．《2019年欧洲肝病学会临床实践指南:药物性肝损伤》精粹及评析[J]．临床肝胆病杂志，2019,35(6):1242-1250.

[12] DUAN ZP,CHEN Y,ZHANG J,et al. Clinical characteristics and mechanism of liver injury in patients with severe acute respiratory syndrome[J]. Chin J Hepatol,2003,11(8):493-496.(in Chinese)段钟平，陈煜，张晶，等．严重急性呼吸道综合征并发肝脏损害的临床特点与机制探讨[J]．中华肝脏病杂志，2003,11(8):493-496.

[13] ZHANG C,SHI L,WANG FS. Liver injury in COVID-19:Management and challenges[J]. Lancet Gastroenterol Hepatol,2020,5(5):428-430.

[14] GUAN YJ,TANG XP,YIN CB,et al. Study on the damage of liver in patients with SARS[J]. Chin Crit Care Med,2004,16(5):267-270.(in Chinese)关玉娟，唐小平，尹炽标，等．SARS患者的肝脏损害[J]．中国危重病急救医学，2004,16(5):267-270.

[15] ALSAAD KO,HAJEER AH,AL BALWI M,et al. Histopathology of Middle East respiratory syndrome coronovirus(MERSCo V)infection-clinicopathological and ultrastructural study[J]. Histopathology,2018,72(3):516-524.

[16] XU Z,SHI L,WANG Y,et al. Pathological findings of COVID-19associated with acute respiratory distress syndrome[J]. Lancet Respir Med,2020,8(4):420-422.

[17] LIU Z,GUO J. Dynamic changes of liver function and myocardial enzyme in 259 patients with severe acute re spiratory syndrome[J]. J Clin Hepatol,2003(3):129-131.

[18] YANG Z,XU M,YI JQ,et al. Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome[J]. Hepatobiliary Pancreat Dis Int,2005,4(1):60-63.

[19] BRIESE T,MISHRA N,JAIN K,et al. Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia[J].m Bio,2014,5(3):e01146-14.

[20] HEMIDA MG,ELMOSLEMANY A,AL-HIZAB F,et al. Dromedary camels and the transmission of Middle East Respiratory Syndrome Coronavirus(MERS-Co V)[J]. Transbound Emerg Dis,2017,64(2):344-353.

[21] AL-HAMEED F,WAHLA AS,SIDDIQUI S,et al. Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah,Saudi Arabia[J]. J Intensive Care Med,2016,31(5):344-348.

[22] SAAD M,OMRANI AS,BAIG K,et al. Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection:A single-center experience in Saudi Arabia[J]. Int J Infect Dis,2014,29:301-306.

[23] ARABI YM,AL-OMARI A,MANDOURAH Y,et al. Critically Ill patients with the Middle East respiratory syndrome:A multicenter retrospective cohort study[J]. Crit Care Med,2017,45(10):1683-1695.

[24] HUANG C,WANG Y,LI X,et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China[J].Lancet,2020,395(10223):497-506.

[25] CHEN N,ZHOU M,DONG X,et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan,China:A descriptive study[J]. Lancet,2020,395(10223):507-513.

[26] SHI H,HAN X,JIANG N,et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan,China:A descriptive study[J]. Lancet Infect Dis,2020,20(4):425-434.

[27] GUAN WJ,NI ZY,HU Y,et al. Clinical characteristics of coronavirus disease 2019 in China[J]. N Engl J Med,2020,382(18):1708-1720.

[28] CAI Q,HUANG D,OU P,et al. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China[J]. Allergy,2020,75(7):1742-1752.

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