肝再生的发生机制及血清标志物的研究现状

李嘉妮; 韩川; 王孝平; 汤善宏; 曾维政

doi:10.3969/j.issn.1001-5256.2020.08.048

肝再生的发生机制及血清标志物的研究现状

DOI: 10.3969/j.issn.1001-5256.2020.08.048

1. 西部战区总医院消化内科
2. 西南交通大学

基金项目:

西部战区总医院军事医学研究项目(2019ZY03)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2020-08-20

Current research on liver regeneration:Pathogenesis and serum markers

Department of Gastroenterology, The General Hospital of Western Theater Command

Research funding:

摘要

摘要:
肝再生是在肝损伤及坏死后,为维持肝脏体积及功能,一系列因子和信号转导通路参与的重要反应。其过程包括三个主要阶段:某些因子引发有丝分裂的初始阶段,促进肝细胞重新进入细胞周期的增殖阶段,促使肝细胞达到一定数量及肝脏质量恢复的终止阶段。介绍了促使各种肝干细胞分化为肝细胞以恢复肝脏体积和功能的各种因子及多种细胞信号通路,并归纳了本课题组前期研究发现——AFP是肝衰竭后肝再生的重要血清标志物。经分析表明,深入研究肝再生的发生基础及临床应用,有助于进一步增加对肝再生的了解,更好预测急慢性肝病的预后,为各种晚期肝病的临床诊治提供新的思路和方法。
- 肝再生 /
- 甲胎蛋白类 /
- 生物标记
Abstract:
Liver regeneration is an important response after liver injury and necrosis to maintain liver volume and function,with the involvement of various factors and signaling pathways.This process has three main stages,i.e.,the initial stage of mitosis triggered by certain factors,the proliferation stage of promoting hepatocytes to enter the cell cycle,and the termination stage of promoting liver cells to reach a certain number and the recovery of liver mass.This article introduces various factors and multiple cellular signaling pathways that promote the differentiation of liver stem cells into liver cells to restore liver volume and function and summarizes the previous research findings of our group that alpha-fetoprotein is an important serum marker for liver regeneration after liver failure.The analysis shows that in-depth studies of the occurrence and clinical application of liver regeneration will help to improve the understanding of liver regeneration,better predict the prognosis of acute and chronic liver diseases,and provide new ideas and methods for the clinical diagnosis and treatment of various advanced liver diseases.
- liver regeneration /
- alpha-fetoproteins /
- biomarkers

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参考文献(38)

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