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Current research on liver regeneration:Pathogenesis and serum markers
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摘要:
肝再生是在肝损伤及坏死后,为维持肝脏体积及功能,一系列因子和信号转导通路参与的重要反应。其过程包括三个主要阶段:某些因子引发有丝分裂的初始阶段,促进肝细胞重新进入细胞周期的增殖阶段,促使肝细胞达到一定数量及肝脏质量恢复的终止阶段。介绍了促使各种肝干细胞分化为肝细胞以恢复肝脏体积和功能的各种因子及多种细胞信号通路,并归纳了本课题组前期研究发现——AFP是肝衰竭后肝再生的重要血清标志物。经分析表明,深入研究肝再生的发生基础及临床应用,有助于进一步增加对肝再生的了解,更好预测急慢性肝病的预后,为各种晚期肝病的临床诊治提供新的思路和方法。
Abstract:Liver regeneration is an important response after liver injury and necrosis to maintain liver volume and function,with the involvement of various factors and signaling pathways.This process has three main stages,i.e.,the initial stage of mitosis triggered by certain factors,the proliferation stage of promoting hepatocytes to enter the cell cycle,and the termination stage of promoting liver cells to reach a certain number and the recovery of liver mass.This article introduces various factors and multiple cellular signaling pathways that promote the differentiation of liver stem cells into liver cells to restore liver volume and function and summarizes the previous research findings of our group that alpha-fetoprotein is an important serum marker for liver regeneration after liver failure.The analysis shows that in-depth studies of the occurrence and clinical application of liver regeneration will help to improve the understanding of liver regeneration,better predict the prognosis of acute and chronic liver diseases,and provide new ideas and methods for the clinical diagnosis and treatment of various advanced liver diseases.
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Key words:
- liver regeneration /
- alpha-fetoproteins /
- biomarkers
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