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Role of pyroptosis in the pathogenesis of acute pancreatitis
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摘要:
急性胰腺炎是常见的消化系统疾病,可出现局部并发症甚至多器官功能衰竭,其发病机制涉及胰酶自身消化、炎症反应、微循环障碍等方面。介绍了细胞焦亡在急性胰腺炎发病机制中的作用,简述了细胞焦亡的激活途径、炎性小体、效应分子对胰腺及胰腺外器官损伤的机制,认为细胞焦亡的调控在急性胰腺炎发病机制中发挥了重要作用,为急性胰腺炎防治提供新的思路。
Abstract:Acute pancreatitis(AP) is a common gastrointestinal disease and may lead to local complications and even multiple organ failure,and the pathogenesis of AP involves self-digestion of trypsin,inflammatory response,and microcirculation disturbance.This article introduces the role of pyroptosis in the pathogenesis of AP and briefly describes the activation pathway of pyroptosis,inflammasome,and the mechanism of action of effector molecules in inducing damage to the pancreas and extra-pancreatic organs.It is believed that the regulation of pyroptosis plays an important role in the pathogenesis of AP,which provides new ideas for the prevention and treatment of AP.
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Key words:
- pancreatitis /
- pyroptosis /
- inflammasomes
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