41例Caroli病的临床特征分析

崔延飞; 余思邈; 田淼; 桑秀秀; 王立福; 孙永强; 景婧; 王仲霞; 王丽苹; 许文涛; 王睿林

doi:10.3969/j.issn.1001-5256.2020.10.020

41例Caroli病的临床特征分析

DOI: 10.3969/j.issn.1001-5256.2020.10.020

1. 河南中医药大学
2. 解放军总医院第五医学中心中西医肝病诊疗与研究中心

基金项目:

国家自然科学基金面上项目(81673806)；保健专项科研课题(17BJZ53)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2020-04-22
- 出版日期: 2020-10-20

Clinical features of Caroli disease: An analysis of 41 cases

Henan University of Traditional Chinese Medicine
Liver Disease Center for Combined TCM and Western Medicine,The Fifth Medical Center of Chinese PLA General Hospital

Research funding:

摘要

摘要: 目的分析Caroli病患者的临床特征。方法收集2015年4月-2020年1月于解放军总医院第五医学中心已确诊的41例Caroli病患者的临床资料,将患者分为Ⅰ型（n=16）和Ⅱ型（n=25）,对两组患者的一般资料、实验室指标及临床特征等进行回顾性分析,满足正态分布的计量资料组间比较采用独立样本t检验,不满足正态分布的组间比较采用Mann-Whitney U检验,计数资料组间比较采用χ2检验,相关性分析采用Spearman相关分析。结果Ⅰ型患者的Alb水平高于Ⅱ型患者（t=0.976,P=0.048）,Ⅱ型患者的PT水平大于Ⅰ型患者（Z=3.115,P=0.001）;Ⅱ型患者食管胃底静脉曲张、上消化道出血和/或黑便、门静脉高压的发生率显著高于Ⅰ型患者（χ2值分别为6.077、5.468、2.403,P值分别为0.002、0.019、0.028）;Ⅱ型患者ChE水平与食管胃底静脉曲张、门静脉高压的发生率呈负相关（r值分别为-0.468、-0.436,P值分别为0.018、0.029）; Alb水平与食管胃底静脉曲张发生率呈负相关（r=-0.561...
- Caroli病 /
- 病理状态,解剖学 /
- 预后
Abstract: Objective To investigate the clinical features of patients with Caroli disease. Methods The clinical data were collected from41 patients who were diagnosed with Caroli disease in The Fifth Medical Center of Chinese PLA General Hospital from April 2015 to January2020,and the patients were divided into type I group with 16 patients and type Ⅱ group with 25 patients. A retrospective analysis was performed for general information,laboratory markers,and clinical features. The independent samples t-test was used for comparison of normally distributed continuous data between groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test was used for comparison of categorical data; a Spearman correlation analysis was also performed. Results The type Ⅰ group had a significantly higher level of albumin( Alb) than the type Ⅱ group( t = 0. 976,P = 0. 048),and the type Ⅱ group had a significantly higher prothrombin time( PT) than the type I group( Z = 3. 115,P = 0. 001). Compared with the type I group,the type Ⅱ group had significantly higher incidence rates of esophageal and gastric varices,upper gastrointestinal bleeding and/or tarry stool,and portal hypertension( χ2= 6. 077,5. 468,and 2. 403,P = 0. 002,0. 019,and 0. 028). In the patients with type Ⅱ Caroli disease,the level of cholinesterase was negatively correlated with the incidence rates of esophageal and gastric varices and portal hypertension( r =-0. 468 and-0. 436,P = 0. 018 and 0. 029); Alb level was negatively correlated with the incidence rate of esophageal and gastric varices( r =-0. 561,P = 0. 004); red blood cell count was negatively correlated with the incidence rates of esophageal and gastric varices,upper gastrointestinal bleeding and/or tarry stool,and portal hypertension( r =-0. 662,-0. 566,and-0. 436,P < 0. 001,P = 0. 003,and P = 0. 029); hemoglobin count was negatively correlated with the incidence rates of esophageal and gastric varices,upper gastrointestinal bleeding and/or tarry stool,and portal hypertension( r =-0. 605,-0. 590,and-0. 510,P = 0. 001,0. 002,and 0. 009); PT was positively correlated with the incidence rates of esophageal varices and portal hypertension( r = 0. 488 and 0. 520,P = 0. 013 and 0. 008).Conclusion Compared with the patients with type I Caroli disease,the patients with type Ⅱ Caroli disease have a higher incidence rates of esophageal and gastric varices,upper gastrointestinal bleeding and/or tarry stool,and portal hypertension,with the changes in clinical indicators such as the decrease of Alb level and the increase of PT level,and they tend to have poor prognosis.
- Caroli disease /
- pathological conditions,anatomical /
- prognosis

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