circRNA在肝细胞癌中的作用机制

郭璇; 谭为; 王昌俊

doi:10.3969/j.issn.1001-5256.2020.10.039

circRNA在肝细胞癌中的作用机制

DOI: 10.3969/j.issn.1001-5256.2020.10.039

1. 华南理工大学医学院
2. 广东省人民医院广东省医学科学院广东省老年医学研究所

基金项目:

国家自然科学基金(81774261)；广东省中医药局课题(20191001,20171001)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2020-04-15
- 出版日期: 2020-10-20

Mechanism of action of circular RNAs in hepatocellular carcinoma

School of Medicine,South China University of Technology
Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Institute of Geriatrics

Research funding:

摘要

摘要: 肝细胞癌(HCC)是全球癌症相关死亡的主要原因之一,存在较高的病死率和复发率,生存率极低。环状RNA (circRNAs)是一类具有组织发育特异性表达模式的单链闭合环状RNA分子,在生物体内发挥调控作用,这些circRNAs通过充当miRNA海绵和靶向蛋白编码基因来调节HCC的进展,但其基本机制仍不清楚。归纳了circRNAs的形成机制及其生物学功能,并综述了circRNAs在HCC发病机制中的作用,提出其作为HCC诊断标志物和治疗靶点的潜在价值。
- 癌,肝细胞 /
- circRNAs /
- 基因表达调控
Abstract: Hepatocellular carcinoma( HCC) is one of the leading causes of cancer-related death worldwide and has high mortality and recurrence rates and low survival rates. Circular RNAs( circRNAs) are a class of single-stranded closed circular RNA molecules with tissue-and development-specific expression and play a regulatory role in organisms. These circRNAs regulate the progression of HCC by acting as miRNA sponges and targeted protein-coding genes,but the basic mechanism is still unclear. This article summarizes the formation mechanism and biological functions of circRNAs,reviews the research advances in the role of circRNAs in the pathogenesis of HCC,and points out their potential value as diagnostic markers and therapeutic targets for HCC.
- carcinoma,hepatocellular /
- circRNAs /
- gene expression regulation

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参考文献(40)

[1] LLOVET JM,ZUCMAN-ROSSI J,PIKARSKY E,et al. Hepatocellular carcinoma[J]. Nat Rev Dis Primers, 2016,2:16018.

[2] LEVRERO M. Viral hepatitis and liver cancer:The case of hepatitis C[J]. Oncogene,2006,25(27):3834-3847.

[3] DE'ANGELIS N,LANDI F,CARRA MC,et al. Managements of recurrent hepatocellular carcinoma after liver transplantation:A systematic review[J]. World J Gastroenterol,2015,21(39):11185-11198.

[4] JECK WR,SORRENTINO JA,WANG K,et al. Circular RNAs are abundant,conserved,and associated with ALU repeats[J]. RNA,2013,19(2):141-157.

[5] QIN M,LIU G,HUO X,et al. Hsa_circ_0001649:A circular RNA and potential novel biomarker for hepatocellular carcinoma[J]. Cancer Biomark,2016,16(1):161-169.

[6] FU L,WU S,YAO T,et al. Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance[J]. J Clin Lab Anal,2018,32(2):e22239.

[7] HSU MT,COCA-PRADOS M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells[J]. Nature,1979,280(5720):339-340.

[8] MENG X,LI X,ZHANG P,et al. Circular RNA:An emerging key player in RNA world[J]. Brief Bioinform,2017,18(4):547-557.

[9] LEE Y,RIO DC. Mechanisms and regulation of alternative premRNA splicing[J]. Annu Rev Biochem,2015,84:291-323.

[10] ZHANG Y,ZHANG XO,CHEN T,et al. Circular intronic long noncoding RNAs[J]. Mol Cell,2013,51(6):792-806.

[11] PIWECKA M,GLAZˇAR P,HERNANDEZ-MIRANDA LR,et al.Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function[J]. Science,2017,357(6357):eaam8526.

[12] LIU G,SHI H,DENG L,et al. Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer[J]. Biochem Biophys Res Commun,2019,513(1):207-212.

[13] ZHENG Q,BAO C,GUO W,et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs[J]. Nat Commun,2016,7:11215.

[14] MEMCZAK S,JENS M,ELEFSINIOTI A,et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.

[15] LI Z,HUANG C,BAO C,et al. Corrigendum:Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol,2017,24(2):194.

[16] PAMUDURTI NR,BARTOK O,JENS M,et al. Translation of circRNAs[J]. Mol Cell,2017,66(1):9-21. e7.

[17] ZHANG M,ZHAO K,XU X,et al. A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma[J]. Nat Commun,2018,9(1):4475.

[18] YANG YB,GAO XY,ZHANG ML,et al. Novel role of FBXW7circular RNA in repressing glioma tumorigenesis[J]. J Natl Cancer Inst,2018,110(3):304-315.

[19] YANG Y,FAN XJ,MAO MW,et al. Extensive translation of circular RNAs driven by N-methyladenosine[J]. Cell Res,2017,27(5):626-641.

[20] DU WW,ZHANG C,YANG W,et al. Identifying and characterizing circRNA-protein interaction[J]. Theranostics,2017,7(17):4183-4191.

[21] DONG W,DAI ZH,LIU FC,et al. The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production[J].EBio Medicine,2019,45:155-167.

[22] ABDELMOHSEN K,PANDA AC,MUNK R,et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1[J]. RNA Biol,2017,14(3):361-369.

[23] ZHANG X,LUO P,JING W,et al. circSMAD2 inhibits the epithelial-mesenchymal transition by targeting miR-629 in hepatocellular carcinoma[J]. Onco Targets Ther,2018,11:2853-2863.

[24] MENG J,CHEN S,HAN JX,et al. Twist1 regulates vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma[J]. Cancer Res,2018,78(15):4150-4162.

[25] LIANG WC,WONG CW,LIANG PP,et al. Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway[J]. Genome Biol,2019,20(1):84.

[26] SUN S,WANG W,LUO X,et al. Circular RNA circ-ADD3 inhibits hepatocellular carcinoma metastasis through facilitating EZH2 degradation via CDK1-mediated ubiquitination[J]. Am J Cancer Res,2019,9(8):1695-1707.

[27] GUO J,DUAN H,LI Y,et al. A novel circular RNA circ-ZNF652promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p[J]. Biochem Biophys Res Commun,2019,513(4):812-819.

[28] FU L,CHEN Q,YAO T,et al. Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma[J]. Oncotarget,2017,8(27):43878-43888.

[29] HAN D,LI J,WANG H,et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J]. Hepatology,2017,66(4):1151-1164.

[30] XU L,FENG X,HAO X,et al. CircSETD3(Hsa_circ_0000567)acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth[J]. J Exp Clin Cancer Res,2019,38(1):98.

[31] HUANG XY,HUANG ZL,HUANG J,et al. Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis[J]. J Exp Clin Cancer Res,2020,39(1):20.

[32] ZHAI Z,FU Q,LIU C,et al. Emerging roles Of hsa-circ-0046600 targeting the miR-640/HIF-1αsignalling pathway in the progression of HCC[J]. Onco Targets Ther,2019,12:9291-9302.

[33] LUO Y,FU Y,HUANG R,et al. CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein1 expression[J]. Cell Death Discov,2019,5:121.

[34] LI J,QIN X,WU R,et al. Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis[J]. J Cell Mol Med,2020,24(9):5152-5161.

[35] CHEN H,LIU S,LI M,et al. circ_0003418 inhibits tumorigenesis and cisplatin chemoresistance through Wnt/β-catenin pathway in hepatocellular carcinoma[J]. Onco Targets Ther,2019,12:9539-9549.

[36] ZHU K,ZHAN H,PENG Y,et al. Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma[J]. Carcinogenesis,2020,41(3):296-302.

[37] CHEN D,ZHANG C,LIN J,et al. Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma[J]. Cancer Manag Res,2018,10:1275-1283.

[38] QU S,YANG X,LI X,et al. Circular RNA:A new star of noncoding RNAs[J]. Cancer Lett,2015,365(2):141-148.

[39] DENG X,CAO M,ZHANG J,et al. Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer[J]. Biomaterials,2014,35(14):4333-4344.

[40] TATOMER DC,LIANG D,WILUSZ JE. Inducible expression of eukaryotic circular RNAs from plasmids[J]. Methods Mol Biol,2017,1648:143-154.

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