肝X受体在非酒精性脂肪性肝病中的作用

李文秘; 王楠; 边倩; 黄倩; 李京涛; 魏海梁; 闫曙光

doi:10.3969/j.issn.1001-5256.2020.10.041

肝X受体在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2020.10.041

1. 陕西中医药大学第一临床医学院
2. 陕西中医药大学附属医院

基金项目:

国家自然科学基金(81603612)；陕西省重点研发计划(2020ZDLSF05-15)；陕西省科技厅基金(2018KJXX-093)；国家级和陕西省大学生创新创业训练计划项目(201810716023,201831023)；陕西中医药大学学科创新团队建设项目(2019-YL05)；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2020-04-21
- 出版日期: 2020-10-20

Role of liver X receptor in nonalcoholic fatty liver disease

The First Clinical Medical College,Shaanxi University of Chinese Medicine
The Affiliated Hospital of Shaanxi University of Chinese Medicine

Research funding:

摘要

摘要: 脂质过量沉积、肝损伤、胰岛素抵抗是非酒精性脂肪性肝病发生发展进程中的标志性特征。肝X受体(LXR)作为DNA转录调节因子,其两种细胞亚型LXRα和LXRβ在调节胆固醇代谢、诱导抗炎和减轻胰岛素抵抗中发挥着关键作用。综述了LXR的结构、功能,LXR与NAFLD发病机制的关系,为NAFLD的预防和治疗提供新思路和新方法。
- 非酒精性脂肪性肝病 /
- 肝X受体 /
- 胆固醇
Abstract: Excessive lipid deposition,liver injury,and insulin resistance are hallmarks in the development and progression of nonalcoholic fatty liver disease( NAFLD). Liver X receptor( LXR) is a transcriptional regulator,and its two cell subtypes,LXRα and LXRβ,play a key role in regulating cholesterol metabolism,inducing anti-inflammation,and reducing insulin resistance. This article reviews the structure and function of LXR and its association with the pathogenesis of NAFLD,in order to provide new ideas and methods for the prevention and treatment of NAFLD.
- non-alcoholic fatty liver disease /
- liver X receptors /
- cholesterol

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参考文献(36)

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