肝肾综合征的发病机制

廖献花; 叶俊钊; 钟碧慧

doi:10.3969/j.issn.1001-5256.2020.11.002

肝肾综合征的发病机制

DOI: 10.3969/j.issn.1001-5256.2020.11.002

中山大学附属第一医院消化内科

基金项目:

国家自然科学基金（81870404）；

详细信息

中图分类号: R575.2;R692
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- 被引次数: 0
出版历程
- 收稿日期: 2020-08-24
- 出版日期: 2020-11-20

Pathogenesis of hepatorenal syndrome

Department of Gastroenterology,The First Affiliated Hospital of Sun Yat-sen University

Research funding:

摘要

摘要:
肝肾综合征（HRS）是终末期肝病患者常见的严重并发症之一。HRS预后差、病死率高,对其发病机制的深入研究有助于精准预防和治疗。虽然目前HRS的确切发病机制仍未完全阐明,但临床对HRS发病机制的研究步伐一直在前进,不仅对经典的机制——内脏血管扩张假说继续丰富完善,而且对全身性炎症、肠道细菌易位在其发病的作用有了新认识,并对心脏功能障碍参与HRS的机制提出了新的心肾综合征概念,更在肾脏病理方面提出了质疑和挑战。对近年来HRS的发病机制研究进展及其对临床工作的启示作一评述。
- 肝硬化 /
- 肝肾综合征 /
- 急性肾损伤 /
- 心肌疾病
Abstract:
Hepatorenal syndrome( HRS) is one of the common serious complications in patients with end-stage liver disease and has poor prognosis and high mortality,and in-depth studies on its pathogenesis will help to achieve precise prevention and treatment. Although the exact pathogenesis of HRS has not yet been fully elucidated,achievements have been made in the pathogenesis of HRS. The classic mechanism of the hypothesis of visceral vasodilation continues to be enriched and perfected,and new understandings have been gained for the role of systemic inflammation and intestinal bacterial translocation in pathogenesis. In addition,a new concept of cardiorenal syndrome is put forward for the involvement of cardiac dysfunction in HRS,and renal pathology has been questioned and challenged. This article reviews the research advances in the pathogenesis of HRS in recent years and related implications for clinical work.
- liver cirrhosis /
- hepatorenal syndrome /
- acute kidney injury /
- cardiomyopathies

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参考文献(34)

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