12例原发性骨髓纤维化合并肝硬化患者的临床特征分析

王宣; 何婷婷; 张宁; 周超; 王葽; 白云峰; 张晶晶; 付双楠; 梁肖肖; 李昕; 宫嫚

doi:10.3969/j.issn.1001-5256.2020.11.025

12例原发性骨髓纤维化合并肝硬化患者的临床特征分析

DOI: 10.3969/j.issn.1001-5256.2020.11.025

解放军总医院第五医学中心中西医结合科

基金项目:

国家科技重大专项（2018ZX10725506-002）；

详细信息

中图分类号: R575.2;R551.3
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出版历程
- 出版日期: 2020-11-20

Clinical characteristics of 12 patients with primary myelofibrosis and liver cirrhosis

Department of Integrative Medicine,The Fifth Medical Center of Chinese PLA General Hospital

Research funding:

摘要

摘要:
<正>原发性骨髓纤维化（primary myelofibrosis,PMF）是由异常造血干细胞的克隆性增殖,导致进行性骨髓纤维化的一种骨髓增殖性肿瘤[1]。有研究[2]发现部分骨髓纤维化患者可出现肝脏硬度值升高。近年来,亦有研究者对PMF合并肝硬化、门静脉高压、消化道出血等进行过临床报道[3-4],但病例数较少。此外,PMF作为一种罕见病,常伴有脾大、门静脉高压、进行性血细胞减少及消化道出血等,与肝硬化表现较为相似,当该病合并肝硬化时,易出现漏诊、误诊。PMF可导致肝硬化,但其进展至肝硬化的间隔时间不详,且无相关临床报道。因此,通过对本院PMF合并肝硬化病例的总结,并结合文献复习,有助于更好地认识PMF与肝硬化之间的关系,对临床早期诊断,减少漏诊、误诊十分重要。
- 原发性骨髓纤维化 /
- 肝硬化 /
- 脾大 /
- 体征和症状
- primary myelofibrosis /
- liver cirrhosis /
- splenomegaly /
- signs and symptoms

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参考文献(15)

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