Diagnosis and treatment of hepatic vascular tumors
-
摘要:
肝脏血管源性肿瘤起源于内皮细胞。除肝海绵状血管瘤外,肝血管源性肿瘤发病率低,临床症状及影像学表现不典型,给临床诊断和治疗带来较大挑战。综述了肝脏血管源性肿瘤的分类、临床诊断、干预措施及预后情况,以期提高对该类疾病的整体认识。
Abstract:Hepatic vascular tumors originate from endothelial cells. Except hepatic cavernous angioma,hepatic vascular tumors tend to have a low incidence rate and atypical clinical symptoms and imaging findings,which brings great challenges to clinical diagnosis and treatment.This article reviews the classification,clinical diagnosis,intervention measures,and prognosis of hepatic vascular tumors,so as to improve the overall understanding of such diseases.
-
Key words:
- liver neoplasms /
- hemangioendothelioma /
- diagnosis /
- therapeutics
-
[1] HASAN HY,HINSHAW JL,BORMAN EJ,et al. Assessing normal growth of hepatic hemangiomas during long-term follow-up[J]. JAMA Surg,2014,149(12):1266-1271. [2] JING L,LIANG H,CAIFENG L,et al. New recognition of the natural history and growth pattern of hepatic hemangioma in adults[J]. Hepatol Res,2016,46(8):727-733. [3] GAO J,FAN RF,YANG JY,et al. Radiofrequency ablation for hepatic hemangiomas:A consensus from a Chinese panel of experts[J]. J Clin Hepatol,2017,33(9):1638-1645.(in Chinese)高君,范瑞芳,杨家印,等.肝血管瘤射频消融治疗(国内)专家共识[J].临床肝胆病杂志,2017,33(9):1638-1645. [4] GAO J,JI JS,DING XM,et al. Laparoscopic radiofrequency ablation for large subcapsular hepatic hemangiomas:Technical and clinical outcomes[J]. PLo S One,2016,11(2):0149755. [5] YUGAWA K,YOSHIZUMI T,HARADA N,et al. Multiple hepatic sclerosing hemangiomas:A case report and review of the literature[J]. Surg Case Rep,2018,4(1):60. [6] OZAKI K,YOSHIKAWA J,YAMAMOTO T,et al. Preoperative diagnosis of the sclerosed hemangioma of the liver using multimodality imaging findings:A case report[J]. Radiol Case Rep,2018,13(5):1025-1029. [7] MIYAMOTO S,OSHITA A,DAIMARU Y,et al. Hepatic sclerosed hemangioma:A case report and review of the literature[J]. BMC Surg,2015,15:45. [8] SUGO H,SEKINE Y,MIYANO S,et al. Hepatic sclerosing hemangioma with predominance of the sclerosed area mimicking a biliary cystadenocarcinoma[J]. Case Reports Hepatol,2018,2018:7353170. [9] XU L,YANG X,KE S,et al. Resection as first-line therapy for large hepatic sclerosing hemangioma:A case report[J].Onco Targets Ther,2019,12:6839-6842. [10] YANG JW,LI Y,XIE K,et al. Spontaneous rupture of hepatic epithelioid hemangioendothelioma:A case report[J]. World J Gastroenterol,2017,23(1):185-190. [11] STUDER LL,SELBY DM. Hepatic epithelioid hemangioendothelioma[J]. Arch Pathol Lab Med,2018,142(2):263-267. [12] LERUT J,IESARI S. Vascular tumours of the liver:A particular story[J]. Transl Gastroenterol Hepatol,2018,3:62. [13] YOUSAF N,MARUZZO M,JUDSON I,et al. Systemic treatment options for epithelioid haemangioendothelioma:The royal marsden hospital experience[J]. Anticancer Res,2015,35(1):473-480. [14] LERUT JP,ORLANDO G,ADAM R,et al. The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma:Report of the European liver transplant registry[J]. Ann Surg,2007,246(6):949-957. [15] SEMENISTY V,NARODITSKY I,KEIDAR Z,et al. Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma-a suitable treatment option:Case report and review of anti-angiogenic treatment options[J]. BMC Cancer,2015,15:402. [16] CHEVREAU C,LE CESNE A,RAY-COQUARD I,et al. Sorafenib in patients with progressive epithelioid hemangioendothelioma:A phase 2 study by the French Sarcoma Group(GSF/GETO)[J]. Cancer,2013,119(14):2639-2644. [17] AGULNIK M,YARBER JL,OKUNO SH,et al. An open-label,multicenter,phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas[J]. Ann Oncol,2013,24(1):257-263. [18] LAKKIS Z,KIM S,DELABROUSSE E,et al. Metronomic cyclophosphamide:An alternative treatment for hepatic epithelioid hemangioendothelioma[J]. J Hepatol,2013,58(6):1254-1257. [19] SOAPE MP,VERMA R,PAYNE JD,et al. Treatment of hepatic epithelioid hemangioendothelioma:Finding uses for thalidomide in a new era of medicine[J]. Case Rep Gastrointest Med,2015,2015:326795. [20] KYRIAZOGLOU A,KOUTSOUKOS K,ZAGOURI F,et al. Metastatic hepatic epithelioid hemangioendothelioma treated with Olaratumab:A falling star rising?[J]. Ther Clin Risk Manag,2020,16:141-146. [21] ZAVRAS N,DIMOPOULOU A,MACHAIRAS N,et al. Infantile hepatic hemangioma:Current state of the art,controversies,and perspectives[J]. Eur J Pediatr,2020,179(1):1-8. [22] PARIA S,MENDIRATTA V,CHANDER R,et al. A study of serum vascular endothelial growth factor in infantile hemangiomas[J].Indian J Dermatol Venereol Leprol,2019,85(1):65-68. [23] LI S,XU G,GAO F,et al. Expression and association of VEGF-Notch pathways in infantile hemangiomas[J]. Exp Ther Med,2017,14(4):3737-3743. [24] FORD JR,GONZALEZ-BARLATAY J,VALENZUELA AA. Early orbital infantile hemangioma that emphasizes the importance of glucose-transporter-1(GLUT-1)[J]. Can J Ophthalmol,2018,53(2):58-60. [25] EHMAN EC,TORBENSON MS,WELLS ML,et al. Hepatic tumors of vascular origin:Imaging appearances[J]. Abdom Radiol(NY),2018,43(8):1978-1990. [26] KROWCHUK DP,FRIEDEN IJ,MANCINI AJ,et al. Clinical practice guideline for the management of infantile hemangiomas[J]. Pediatrics,2019,143(1):e20183475. [27] ERNST L,GRABHORN E,BRINKERT F,et al. Infantile hepatic hemangioma:Avoiding unnecessary invasive procedures[J].Pediatr Gastroenterol Hepatol Nutr,2020,23(1):72-78. [28] COPPOLA A,BIANCO G,ARDITO F,et al. Primary hepatic angiosarcoma[J]. ANZ J Surg,2018,88(1-2):e75-e76. [29] WILSON GC,LLUIS N,NALESNIK MA,et al. Hepatic angiosarcoma:A multi-institutional,international experience with44 cases[J]. Ann Surg Oncol,2019,26(2):576-582. [30] WANG J,LI Q,CUI YL,et al. Hepatic angiosarcoma:An analysis of 16 cases[J]. Chin J Hepatobiliary Surg,2006,12(8):532-535.(in Chinese)王健,李强,崔云龙,等.肝血管肉瘤:16例回顾[J].中华肝胆外科杂志,2006,12(8):532-535. [31] BONACCORSI-RIANI E,LERUT JP. Liver transplantation and vascular tumours[J]. Transpl Int,2010,23(7):686-691. [32] LERUT JP,WEBER M,ORLANDO G,et al. Vascular and rare liver tumors:A good indication for liver transplantation?[J]. J Hepatol,2007,47(4):466-475. [33] KIM HR,RHA SY,CHEON SH,et al. Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma[J]. Ann Oncol,2009,20(4):780-787. [34] SINDHU S,GIMBER LH,CRANMER L,et al. Angiosarcoma treated successfully with anti-PD-1 therapy-a case report[J]. J Immunother Cancer,2017,5(1):58. [35] CHANG SD,SAKAMOTO GT. The role of radiosurgery for hemangiopericytomas[J]. Neurosurg Focus,2003,14(5):e14. [36] DEL ROSARIO ML,SALEH A. Preoperative chemotherapy for congenital hemangiopericytoma and a review of the literature[J]. J Pediatr Hematol Oncol,1997,19(3):247-250. [37] PARK MS,PATEL SR,LUDWIG JA,et al. Activity of temozolomide and bevacizumab in the treatment of locally advanced,recurrent,and metastatic hemangiopericytoma and malignant solitary fibrous tumor[J]. Cancer,2011,117(21):4939-4947. [38] MAKI RG,D'ADAMO DR,KEOHAN ML,et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas[J]. J Clin Oncol,2009,27(19):3133-3140. [39] STACCHIOTTI S,NEGRI T,PALASSINI E,et al. Sunitinib malate and figitumumab in solitary fibrous tumor:Patterns and molecular bases of tumor response[J]. Mol Cancer Ther,2010,9(5):1286-1297. [40] JUNG DH,HWANG S,HONG SM,et al. Clinico-pathological correlation of hepatic angiomyolipoma:A series of 23 resection cases[J]. ANZ J Surg,2018,88(1-2):60-65. [41] LIU J,ZHANG CW,HONG DF,et al. Primary hepatic epithelioid angiomyolipoma:A malignant potential tumor which should be recognized[J]. World J Gastroenterol,2016,22(20):4908-4917. [42] KUBO H,YAMAZAKI H,OKADA T,et al. Primary hepatic angiomyolipoma:Immunohistochemistry and electron microscopic observations:A case report[J]. J Med Case Rep,2017,11(1):76. [43] GU T,WANG J,CHEN XQ,et al. Hepatic angiomyolipoma:A case report and literature review[J]. J Jilin Univ(Med Edit),2019,45(1):153-155,219.(in Chinese)顾腾,王江,陈晓倩,等.肝血管平滑肌脂肪瘤1例报告及文献复习[J].吉林大学学报(医学版),2019,45(1):153-155,219. [44] HUANG YM,WEI PL,CHEN RJ. Epithelioid angiomyolipoma of the liver[J]. J Gastrointest Surg,2018,22(1):175-176. [45] WANG WT,LI ZQ,ZHANG GH,et al. Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma:A case report[J]. World J Gastroenterol,2015,21(12):3755-3758.
计量
- 文章访问数: 1182
- HTML全文浏览量: 51
- PDF下载量: 121
- 被引次数: 0