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Research advances in the serological diagnosis of nonalcoholic fatty liver disease
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摘要:
近年来非酒精性脂肪性肝病（NAFLD）的患病率明显升高,已逐渐成为我国常见的慢性肝病之一。而NAFLD相关终末期或恶化性肝病患者已成为肝移植的主要人群之一。NAFLD发病率的增加和非酒精性脂肪性肝炎（NASH）的严重后果使得有必要使用有效的方法来识别NAFLD。基于此,总结了目前血清学方法诊断NAFLD,包括脂肪变性、NASH和肝纤维化,并探讨了其优缺点。尽管大部分血清标志物真正应用于临床的价值有限,但血清标志物模型在诊断肝脂肪变性及评估纤维化程度和初步筛查方面均有较好的应用前景。由于联合不同血清学模型可以提高诊断的准确度,因此开展多角度、多中心的联合诊断将是未来的研究热点。
Abstract:In recent years,the prevalence rate of nonalcoholic fatty liver disease( NAFLD) has increased significantly and NAFLD has gradually become one of the common chronic liver diseases in China. Patients with NAFLD-related end-stage or deteriorative liver diseases have become one of the main populations for liver transplantation. The increasing prevalence rate of NAFLD and the severe outcomes of nonalcoholic steatohepatitis( NASH) make it necessary to use effective methods to identify NAFLD. Therefore,this article summarizes the current serological methods for the diagnosis of NAFLD,including steatosis,NASH,and liver fibrosis,and discusses their advantages and disadvantages. Although most of the serum markers have limited clinical value,serum marker models have a good application prospect in the diagnosis of hepatic steatosis,the evaluation of fibrosis degree,and preliminary screening. Since a combination of different serological models can improve the accuracy of diagnosis,multi-angle and multicenter joint diagnosis will be a research hotspot in the future.
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Key words:
- nonalcoholic fatty liver disease /
- diagnosis /
- biomarkers
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