mTOR相关信号通路介导的自噬对肝损伤的调控作用

黄倩; 李京涛; 刘永刚; 魏海梁; 闫曙光; 郭英君; 常占杰

doi:10.3969/j.issn.1001-5256.2020.11.051

mTOR相关信号通路介导的自噬对肝损伤的调控作用

DOI: 10.3969/j.issn.1001-5256.2020.11.051

1. 陕西中医药大学第一临床医学院
2. 陕西中医药大学附属医院肝病一科
3. 陕西中医药大学附属医院普外一科
4. 陕西中医药大学基础医学院
5. 宁夏回族自治区人民医院感染疾病科

基金项目:

国家自然科学基金（81603612,81904192）；陕西省重点研发计划（2020ZDLSF05-15）；陕西省科技厅科研基金（2018KJXX-093）；陕西省“特支计划”区域发展人才项目（2017）；宁夏回族自治区自然科学基金（NZ17278）；陕西中医药大学学科创新团队建设项目（2019-YL05）；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2020-05-13
- 出版日期: 2020-11-20

Regulatory effect of mTOR pathway-mediated autophagy in liver injury

The First Clinical Medical College,Shaanxi University of Chinese Medicine
First Department of Hepatology,The Affiliated Hospital of Shaanxi University of Chinese Medicine
First Department of General Surgery,The Affiliated Hospital of Shaanxi University of Chinese Medicine
College of Basic Medicine,Shaanxi University of Chinese Medicine
Department of Infectious Disease,The People's Hospital of Ningxia Hui Autonomous Region

Research funding:

摘要

摘要:
自噬能调节肝脏生理、平衡肝脏代谢。自噬激活对肝损伤的作用是双面、复杂的,受多种因素调控,与多种蛋白通路相关联。总结了mTOR机制靶点在自噬调节中的作用,其通过PI3K/AKT上游信号通路相应地抑制或增强自噬水平,参与相关肝脏疾病的生理病理变化。故而综述mTOR/PI3K/AKT自噬通路在肝损伤方面的研究进展,旨在为相关肝脏疾病提供新的治疗靶点。
- 自噬 /
- 肝损伤 /
- 哺乳动物雷帕霉素靶蛋白 /
- 信号传导
Abstract:
Autophagy can regulate liver physiology and balance liver metabolism. Autophagy activation has a double-sided and complex effect on liver injury,and it is regulated by many factors and is associated with many protein pathways. This article summarizes the role of m TOR in the regulation of autophagy,which can inhibit or enhance autophagy through the PI3 K/Akt upstream signaling pathway and participate in the physiological and pathological changes of related liver diseases. Therefore,this article reviews the research advances in the m TOR/PI3 K/Akt autophagy pathway in liver injury,in order to provide new therapeutic targets for related liver diseases.
- autophagy /
- liver injury /
- mammalian target of rapamycin /
- signal transduction

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