嗜肝病毒阴性肝病的病因分析

郝大昂; 刘晔; 颜学兵

doi:10.3969/j.issn.1001-5256.2020.12.019

嗜肝病毒阴性肝病的病因分析

DOI: 10.3969/j.issn.1001-5256.2020.12.019

1. 徐州医科大学研究生院
2. 徐州医科大学附属医院感染及肝病科

基金项目:

国家自然科学基金（81371867）；国家级十三五计划国家科技重大专项项目（2018111010）；江苏省医学科技专项-新型临床诊疗技术攻关（BL2014033）；江苏省医学重点人才培养基金（BRA2015506）；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2020-06-16
- 出版日期: 2020-12-20

An etiological analysis of liver diseases with negative hepatotropic virus

Graduate School,Xuzhou Medical University
Department of Infection and Liver Diseases,The Affiliated Hospital of Xuzhou Medical University

Research funding:

摘要

摘要:
目的分析嗜肝病毒阴性肝病的病因,为肝脏疾病的临床诊治提供思路。方法回顾性分析2018年7月-2019年12月在徐州医科大学附属医院感染科收治的113例嗜肝病毒阴性肝病患者的临床资料及肝脏穿刺活组织检查结果,根据性别分为男性组（n=41）和女性组（n=72）,根据年龄分为青年组（n=42）、中年组（n=56）和老年组（n=15）。计数资料组间比较采用χ2检验。结果 113例嗜肝病毒阴性肝病患者中,最终明确病因病例111例（98. 23%）。非酒精性脂肪性肝病（NAFLD） 43例（38. 05%）、药物性肝损伤（DILI） 40例（35. 40%）、自身免疫性肝病（AILD） 16例（14. 15%）、酒精性肝病（ALD） 8例（7. 08%）、胆道系统疾病3例（2. 65%）、其他系统疾病累及肝脏1例（0. 88%）。男性患者以NAFLD（53. 49%）、ALD（100%）、DILI（15. 00%）为主,女性患者以DILI（85. 00%）、NAFLD（46. 51%）、AILD（93. 75%）为主。DILI中女性患者明显多于男性（χ2=40. 000,P<0. 001）...
- 肝疾病 /
- 嗜肝病毒属 /
- 活组织检查,针吸
Abstract:
Objective To investigate the etiology of liver diseases with negative hepatotropic virus,and to provide ideas for the clinical diagnosis and treatment of liver diseases. Methods A retrospective analysis was performed for the clinical data and liver biopsy results of 113 patients with negative hepatotropic virus who were admitted to The Affiliated Hospital of Xuzhou Medical University from July 2018 to December 2019. According to sex,they were divided into male group with 41 patients and female group with 72 patients,and according to age,they were divided into youth group with 42 patients,middle-aged group with 56 patients,and elderly group with 15 patients. The chi-square test was used for comparison of categorical data between groups. Results Among the 113 patients with negative hepatotropic virus,111( 98. 23%) were given a confirmed diagnosis,among whom 43( 38. 05%) were diagnosed with nonalcoholic fatty liver disease( NAFLD),40( 35. 40%) were diagnosed with drug-induced liver injury( DILI),16( 14. 15%) had autoimmune liver disease( AILD),8( 7. 08%) had alcoholic liver disease,3( 2. 65%) had biliary disease,and 1( 0. 88%) had diseases in other systems which involved the liver. Among the male patients,53. 49% had NAFLD,100% had ALD,and 15% had DILI,while among the female patients,85% had DILI,46. 51% had NAFLD,and 93. 75% had AILD. For DILI,there were significantly more female patients than male patients( χ2=40. 000,P < 0. 001),and for AILD,there were also significantly more female patients than male patients( χ2= 12. 250,P < 0. 001). In the youth group,NAFLD( 55. 81%),DILI( 20%),and ALD( 75%) were the main causes of disease,and DILI was the main cause in the middle-aged group and the elderly group. Among the patients with NAFLD,there were significantly more patients in the youth group than in the elderly group( χ2= 16. 333,P < 0. 001); among the patients with DILI,there were significantly more patients in the middle-aged group than in the youth group( χ2= 8. 000,P = 0. 005); among the patients with AILD,there were significantly more patients in the middle-aged group than in the youth group( χ2= 8. 333,P = 0. 004). Conclusion Most liver diseases with negative hepatotropic virus can be diagnosed by liver biopsy,and NAFLD,DILI,and AILD are the main causes. Patients with different sexes and ages have different etiologies.
- liver diseases /
- hepatovirus /
- biopsy,needle

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