Research advances in the pathogenesis of alcoholic liver disease
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摘要:
酒精性肝病(ALD)是肝功能障碍和肝相关疾病死亡的常见原因,给人类健康和社会发展带来了极大危害。氧化应激、肠道微生物改变、遗传变异、自噬抑制、microRNA等许多因素被认为参与了ALD的发生发展。现就这些因素在ALD中的作用机制作一概述,以期为治疗ALD和发现新的药物靶点提供依据。
Abstract:Alcoholic liver disease( ALD) is a common cause of liver dysfunction and death due to liver-related diseases,which brings great harm to human health and social development. Many factors are involved in the development and progression of ALD,such as oxidative stress,change in gut microbiota,genetic variation,autophagy inhibition,and microRNAs. This article summarizes the mechanism of action of these factors in ALD,in order to provide a basis for the treatment of ALD and the discovery of new drug targets.
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