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Current status of the research on targeted therapy for cholangiocarcinoma
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摘要:
胆管癌是指来源于胆管上皮的恶性肿瘤,虽发病率低,但因其发病时无突出的临床表现,发现时多为终末期。目前面临治疗手段不足、预后不佳、生存率低等问题,所以迫切需要找到新的治疗方式来突破胆管癌治疗的瓶颈。随着对胆管癌基因图谱表达研究的深入和下一代基因测序技术的发展,已经发现了一些潜在的靶点,如FGFR、IDH1/2等,使靶向治疗胆管癌成为一种可行的治疗手段。靶向治疗是指通过干扰肿瘤细胞生长涉及的特异性分子来阻断肿瘤细胞的生长,具有特异性高、毒性低、疗效可观等优点。近来,靶向治疗已经逐渐成为胆管癌治疗的研究热点,阐述了胆管癌靶向治疗的现状和面临的问题。
Abstract:Cholangiocarcinoma is a malignant tumor originating from the epithelium of bile ducts,and although it has a low incidence rate,most patients are in the end stage at the time of diagnosis since there are no prominent clinical manifestations at disease onset. Since there are problems such as insufficient treatment options,poor prognosis,and low survival rates,it is urgent to find new treatment methods to make breakthroughs in the treatment of cholangiocarcinoma. With the in-depth studies on cholangiocarcinoma gene mapping and the development of next-generation sequencing technologies,a number of potential targets have been discovered,such as FGFR and IDH1/2,making targeted therapy for cholangiocarcinoma a feasible treatment option. Targeted therapy is a treatment modality that blocks the growth of tumor cells by interfering with the specific molecules involved in tumor cell growth,with the advantages of high specificity,low toxicity,and considerable therapeutic effect. In recent years,targeted therapy has become a research hotspot in the treatment of cholangiocarcinoma. This article elaborates on the current status and challenges in targeted therapy for cholangiocarcinoma.
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Key words:
- bile duct neoplasms /
- molecular targeted therapy /
- therapeutics
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