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肝纤维化中上皮间质转化的调控及靶向治疗的研究进展
DOI: 10.3969/j.issn.1001-5256.2021.01.035
作者贡献声明：王永娟负责课题设计，资料分析，撰写论文；谢肖立参与收集数据，修改论文；姜慧卿负责拟定写作思路，指导撰写文章并最后定稿。
Research advances in the regulation of epithelial-mesenchymal transition and targeted therapy for liver fibrosis
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摘要: 肝纤维化的病理基础是细胞外基质沉积，肌成纤维细胞是细胞外基质的主要来源。上皮间质转化(EMT)是肌成纤维细胞的产生机制之一。目前大量研究表明，以EMT关键分子及信号通路为靶点进行干预，可减轻肝纤维化。回顾了相关文献，对EMT相关的信号通路、重要调控分子和以EMT为靶点治疗肝纤维化的药物进行综述，以期为治疗肝纤维化提供新思路。Abstract: The pathological basis of liver fibrosis is the deposition of extracellular matrix (ECM), and myofibroblasts are the main source of ECM. Epithelial-mesenchymal transition (EMT) is one of production mechanisms of myofibroblasts. At present, a large number of studies have shown that intervention of key EMT molecules and signaling pathways as targets can reduce liver fibrosis. Based on literature review, this article summarizes the signaling pathways associated with EMT, important regulatory molecules, and drugs targeting EMT in the treatment of liver fibrosis, so as to provide new ideas for the treatment of liver fibrosis.
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Key words:
- Liver Cirrhosis /
- Epithelial-Mesenchymal Transition /
- Therapeutics
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