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肝细胞癌早期诊断中的生物标志物
DOI: 10.3969/j.issn.1001-5256.2021.01.038
作者贡献声明：刘熙称负责课题设计，撰写论文；刘熙称、王艺颖、童曼曼参与文献搜集，修改论文；秦俊杰负责拟定写作思路，指导撰写文章并最后定稿。
Biomarkers for the early diagnosis of hepatocellular carcinoma
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摘要: 晚期肝细胞癌(HCC)患者预后通常较差，如若能早期诊断，并采取行之有效的治疗措施则可显著提高患者生存率。目前，AFP是检测HCC应用最广泛的血清标志物。然而，在一些HCC患者中并未发现AFP的升高。分析了AFP、乙型肝炎核心相关抗原、液体活检技术、微小RNA、长链非编码RNA及外泌体在HCC早期诊断中的应用潜力，通过探讨其研究进展，为HCC早期诊断方法的探索提供依据。Abstract: Patients with advanced hepatocellular carcinoma (HCC) often have poor prognosis, and early diagnosis and effective treatment measures can significantly improve the survival rate of patients. At present, alpha-fetoprotein (AFP) is the most widely used serum marker for the diagnosis of HCC in the world; however, no increase in AFP was found in some HCC patients. This article analyzes the application potential of AFP, hepatitis B core-related antigen, liquid biopsy technology, microRNA, long non-coding RNA, and exosomes in the early diagnosis of HCC and reviews related research advances, so as to provide a basis for exploring new methods for the early diagnosis of HCC.
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Key words:
- Carcinoma, Hepatocellular /
- Early Diagnosis /
- Biomarkers, Tumor
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