联合肝脏离断和门静脉结扎的二步肝切除术在不可切除肝细胞癌中的应用

林伯辉; 区奕猛

doi:10.3969/j.issn.1001-5256.2021.01.039

联合肝脏离断和门静脉结扎的二步肝切除术在不可切除肝细胞癌中的应用

DOI: 10.3969/j.issn.1001-5256.2021.01.039

广东药科大学附属第一医院肝胆外科，广州 510000

作者贡献声明：林伯辉负责收集文献，资料分析，撰写并修改文章；区奕猛负责拟定写作思路，指导撰写, 修改文章并最后定稿。

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2020-05-07
- 录用日期: 2020-07-06
- 出版日期: 2021-01-20

Application of associating liver partition and portal vein ligation for staged hepatectomy in unresectable hepatocellular carcinoma

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510000, China

摘要

摘要: 对于残余肝体积不足的肝细胞癌患者，联合肝脏离断合并门静脉结扎的二步肝切除术(ALPPS)可以达到快速增大残余肝体积并切除肿瘤的目的，但仍有其弊端和未知性存在。ALPPS作为肝胆领域的新技术，在问世的10余年来，其适用范围在扩展，技术得到进一步改良。概述国内外对肝细胞癌患者施行ALPPS的经验，分析ALPPS在肝细胞癌患者应用中的关键问题，探讨其在靶向治疗和免疫治疗盛行时代中的机遇和挑战。
- 癌，肝细胞 /
- 肝切除术 /
- 治疗学
Abstract: For hepatocellular carcinoma patients with insufficient residual liver volume, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can achieve the goal of rapidly increasing residual liver volume and removing the tumor, but there are still drawbacks and uncertainties. As a new technique in the field of hepatobiliary surgery, the range of application of ALPPS has been expanded and its technique has been further improved in the past 10 years since its inception. This article summarizes the experience in implementing ALPPS in patients with hepatocellular carcinoma in China and globally, analyzes the key issues of the application of ALPPS in hepatocellular carcinoma patients, and discusses its opportunities and challenges in the era of targeted therapy and immunotherapy.
- Carcinoma, Hepatocellular /
- Hepatectomy /
- Therapeutics

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参考文献(47)

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