新型冠状病毒肺炎合并肝损伤的发生机制

李璐; 李爽; 陈煜

doi:10.3969/j.issn.1001-5256.2021.01.046

新型冠状病毒肺炎合并肝损伤的发生机制

DOI: 10.3969/j.issn.1001-5256.2021.01.046

李璐^{1a, 2},
李爽^{1b, 2},
陈煜^{1a, 2,}

1a.
首都医科大学附属北京佑安医院肝病中心四科，北京 100069
1b.
首都医科大学附属北京佑安医院血液透析室，北京 100069
2.
肝衰竭与人工肝治疗研究北京市重点实验室，北京 100069

基金项目:

国家重点研发计划资助 (2017YFA0103000);

国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治” (2017ZX10203201-005);

北京市医院管理局临床医学发展专项经费资助 (ZYLX201806);

白求恩医学科学研究基金资助项目 (SG068FN)

作者贡献声明：李璐、李爽负责查阅文献；李璐负责撰写文章；陈煜负责指导撰写、修改文章，并最后定稿。

详细信息

作者简介:
李璐（1986—），女，主治医师，主要从事肝病研究

通信作者:
陈煜, chybeyond1071@ccmu.edu.cn

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-04
- 录用日期: 2020-07-30
- 出版日期: 2021-01-20

Pathogenesis of coronavirus disease 2019 with liver injury

Lu LI^{1a, 2},
Shuang LI^{1b, 2},
Yu CHEN^{1a, 2
,}

1a.
Hepatology Center Department 4, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
1b.
Hemodialysis Room, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
2.
Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China

摘要

摘要: 新型冠状病毒肺炎已对全球公共卫生造成了重大威胁。除呼吸系统外，部分患者可出现不同程度的肝损伤。基于相关文献，对病原学特征及其致病机制进行分析，初步探讨导致新型冠状病毒肺炎合并肝损伤出现的原因可能有病毒的直接作用、炎性细胞因子风暴、药物性肝损伤、低氧性肝损伤及免疫功能障碍等。建议临床可选择合理药物进行护肝治疗，减少肝损伤的发生。
- 新型冠状病毒肺炎 /
- 化学性与药物性肝损伤 /
- 治疗学
Abstract: Coronavirus disease 2019 (COVID-19) has become a major threat to global public health. In addition to injury in the respiratory system, some patients may have varying degrees of liver injury. With reference to related articles, this article analyzes the etiological characteristics and pathogenesis of COVID-19 and discusses the possible causes of COVID-19 with liver injury, including the direct effect of virus, inflammatory cytokine storm, drug-induced liver injury, hypoxic liver injury, and immune dysfunction. It is suggested that reasonable drugs should be selected in clinical practice to protect the liver and reduce the incidence rate of liver injury.
- Coronavirus Disease 2019 /
- Chemical and Drug Induced Liver Injury /
- Therapeutics

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参考文献(31)

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