microRNA在自身免疫性肝病中的作用

蔡萌强; 刘素彤; 刘君颖; 张丽慧; 赵文霞

doi:10.3969/j.issn.1001-5256.2021.01.047

microRNA在自身免疫性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2021.01.047

1.
河南中医药大学第一临床医学院，郑州 450000
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

河南省中医药科学研究重点专项课题 (2018JDZX005);

国家中医药管理局全国名老中医药传承工作室建设项目 (国中医药人教函〔2018〕134号);

河南省自然科学基金 (162300410183)

作者贡献声明：蔡萌强负责资料收集、撰写论文；刘素彤、刘君颖、张丽慧负责修改论文；赵文霞负责拟定研究方向、写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
蔡萌强(1995—)，男，从事中医药防治消化系统疾病研究

通信作者:
赵文霞，zhao-wenxia@163.com

中图分类号: R575.1
计量
- 文章访问数: 536
- HTML全文浏览量: 137
- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-05
- 录用日期: 2020-07-23
- 出版日期: 2021-01-20

The role of microRNA in autoimmune liver diseases

1.
The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China

摘要

摘要: microRNA(miRNA)通过抑制靶基因转录后翻译，影响细胞分化、增殖与凋亡等生物学过程，广泛参与调节生物体内的免疫与炎症反应。自身免疫性肝病是一种异常免疫介导的肝胆系统慢性炎症性疾病，miRNA参与的肝组织异常免疫炎症反应与自身免疫性肝病的发生发展过程密切相关。现就当前miRNA在自身免疫性肝病中的研究进展作一综述。
- 微RNAs /
- 肝炎, 自身免疫性 /
- 肝硬化, 胆汁性 /
- 胆管炎, 硬化性
Abstract: MicroRNA(miRNA) affect various biological processes such as cell differentiation, proliferation, and apoptosis by inhibiting the translation of target genes after transcription and are widely involved in the regulation of immune and inflammatory responses in organisms. Autoimmune liver diseases are a group of chronic inflammatory diseases of the hepatobiliary system mediated by abnormal immunity, and abnormal immune inflammatory response of liver tissue with the involvement of miRNA is closely associated with the development and progression of autoimmune liver diseases. This article reviews the current research advances in miRNA in autoimmune liver diseases.
- microRNAs /
- Hepatitis, Autoimmune /
- Liver Cirrhosis, Biliary /
- Cholangitis, Sclerosing

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参考文献(42)

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