肠道菌群及其代谢产物在重症急性胰腺炎相关急性呼吸窘迫综合征中的作用

熊洋洋; 吴东; 钱家鸣

doi:10.3969/j.issn.1001-5256.2021.01.052

肠道菌群及其代谢产物在重症急性胰腺炎相关急性呼吸窘迫综合征中的作用

DOI: 10.3969/j.issn.1001-5256.2021.01.052

中国医学科学院，北京协和医学院，北京协和医院消化内科，北京 100730

基金项目:

北京市自然科学基金面上项目 (7192162);

中国医学科学院临床与转化医学研究项目 (2019XK320036)

作者贡献声明：熊洋洋负责检索文献，资料分析，撰写论文；吴东和钱家鸣负责拟定写作思路，修改论文，指导撰写文章并最后定稿。

详细信息

作者简介:
熊洋洋(1989—)，男，主要从事急性胰腺炎、炎症性肠病方面的研究

通信作者:
吴东，wudong@pumch.cn

中图分类号: R576
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- 被引次数: 0
出版历程
- 收稿日期: 2020-06-03
- 录用日期: 2020-06-28
- 出版日期: 2021-01-20

Role of gut microbiota and its metabolites in severe acute pancreatitis-related acute respiratory distress syndrome

Chinese Academy of Medical Sciences; Peking Union Medical College; Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China

摘要

摘要: 急性呼吸窘迫综合征(ARDS)是重症急性胰腺炎(SAP)常见的并发症，也是导致SAP患者早期死亡的首要原因，目前发病机制尚不清楚。近年来肠道菌群及其代谢产物参与调控SAP相关ARDS日益受到关注，深入探究“肠-肺轴”的发病机制有助于为SAP-ARDS的药物研发提供新的思路。总结了近年来肠道菌群及其代谢产物在SAP-ARDS领域的研究进展。
- 胰腺炎 /
- 胃肠道微生物组 /
- 呼吸窘迫综合征，成人
Abstract: Acute respiratory distress syndrome (ARDS) is a common complication of severe acute pancreatitis (SAP) and a leading cause of early death in SAP patients, but its pathogenesis is still unclear. In recent years, the role of gut microbiota and its metabolites in regulating SAP-related ARDS has attracted more and more attention, and in-depth studies on the pathogenesis of "intestine-lung axis" may provide new ideas for the research and development of drugs for SAP-related ARDS. This article summarizes the recent research advances in gut microbiota and its metabolites in SAP-related ARDS.
- Pancreatitis /
- Gastrointestinal Microbiome /
- Respiratory Distress Syndrome, Adult

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