microRNA-125b在多种慢性肝病发生发展中的作用
DOI: 10.3969/j.issn.1001-5256.2021.03.046
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:卢能源负责文献检索, 文章思路设计, 论文撰写与修订;王佳慧、钟芳菲、汪磊、彭岳负责文献检索与资料分析;,赵铁建、郑洋负责指导撰写文章及最后定稿。
Role of microRNA-125b in the development and progression of various chronic liver diseases
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摘要: 微小RNA(miRNA)是一类非编码的小分子RNA,是基因表达的转录后调控因子。简述了多种慢性肝病,包括代谢功能障碍相关性脂肪性肝病、慢性乙型肝炎、慢性丙型肝炎、慢性药物性肝损伤、肝硬化以及肝细胞癌的相关病因,归纳了近年来关于miR-125b通过靶向不同的靶基因,进入不同的信号转导途径而在同一肝病或病理进程中发挥着相同或相悖的调控作用的相关报道,以期为多种慢性肝病的发病机制研究和非创伤性鉴别手段的建立提供相关见解。Abstract: MicroRNA (miRNA) is a type of small non-coding RNA and acts as a post-transcriptional regulator of gene expression. This article briefly describes the etiology of various chronic liver diseases, including metabolic dysfunction-associated fatty liver disease, chronic hepatitis B, chronic hepatitis C, chronic drug-induced liver injury, liver cirrhosis, and hepatocellular carcinoma, and summarizes related reports on microRNA-125b which enters different signal transduction pathways and plays the same or contradictory regulatory role in the same liver disease or pathological process by targeting different target genes, so as to provide insights into the research on the pathogenesis of various chronic liver diseases and the establishment of non-invasive differential methods.
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Key words:
- MicroRNAs /
- Liver Diseases /
- Gene Expression Regulation
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