代谢相关脂肪性肝病慢加急性肝衰竭的过去、现状与未来

缪磊; 唐梁杰; 范建高; 郑明华

doi:10.3969/j.issn.1001-5256.2021.04.004

代谢相关脂肪性肝病慢加急性肝衰竭的过去、现状与未来

DOI: 10.3969/j.issn.1001-5256.2021.04.004

缪磊^{1, 2},
唐梁杰¹,
范建高^{3, 4, ,},
郑明华^{1, 5, 6, ,}

1.
温州医科大学附属第一医院感染内科/脂肪肝中心，浙江温州 325000
2.
温州医科大学附属第二医院，育英儿童医院消化内科，浙江温州 325000
3.
上海交通大学医学院附属新华医院消化内科，上海 200092
4.
上海市小儿消化与营养重点实验室，上海 200092
5.
温州医科大学肝病研究所，浙江温州 325000
6.
浙江省慢性肝病重症化精准诊治与转化重点实验室，浙江温州 325000

基金项目:

国家自然科学基金项目 (81500665);

国家自然科学基金项目 (82070588);

浙江省卫生厅高层次创新人才项目 (S2032102600032);

温州市新世纪551人才项目

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：缪磊、郑明华对研究设计有关键贡献；唐梁杰参与了文献资料的获取分析过程；缪磊、范建高、郑明华参与了起草或修改文章关键内容。

详细信息

作者简介:
缪磊(1992—)，男，博士，主要从事脂肪性肝病的基础和临床研究

通信作者:
范建高，fanjiangao@xinhuamed.com.cn

郑明华，zhengmh@wmu.edu.cn

中图分类号: R575.5
计量
- 文章访问数: 716
- HTML全文浏览量: 168
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- 被引次数: 0
出版历程
- 收稿日期: 2020-12-20
- 录用日期: 2021-01-05
- 出版日期: 2021-04-20

Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future

Lei MIAO^{1, 2},
Liangjie TANG¹,
Jiangao FAN^{3, 4
, ,},
Minghua ZHENG^{1, 5, 6
, ,}

1.
NAFLD Research Center/Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
2.
Department of Gastroenterology, Yuying Children's Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
3.
Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
4.
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
5.
Institute of Hepatology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
6.
Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang 325000, China

Research funding:

(81500665);

(82070588);

(S2032102600032);

摘要

摘要: 代谢相关脂肪性肝病(MAFLD)是目前脂肪性肝病领域的热议话题，它已成为全球最常见的慢性肝病。预计在未来的20年内，MAFLD及相关肝硬化的发病率仍将不断增加，成为新的全球性健康问题。慢加急性肝衰竭(ACLF)是指在慢性肝病基础上，短期内发生的急性或亚急性肝功能失代偿状态，以腹水、黄疸、凝血功能障碍和肝性脑病为主要表现的临床症候群。在有限的资料基础上，对MAFLD-ACLF的流行病学、发病机制和治疗管理策略等问题进行讨论和展望。
- 代谢相关脂肪性肝病 /
- 慢加急性肝功能衰竭 /
- 肝移植
Abstract: Metabolic associated fatty liver disease (MAFLD) is a hotspot in the field of fatty liver disease at present and it has become the most common chronic liver disease around the world. It is predicted that the incidence rates of MAFLD and related liver cirrhosis will continue to grow in the next 20 years and that they will become new global health issues. Acute-on-chronic liver failure (ACLF) is defined as a clinical syndrome of acute or subacute liver function decompensation within a short period of time in the presence of existing chronic liver diseases, with the main clinical manifestations of ascites, jaundice, coagulation disorder, and hepatic encephalopathy. Based on the existing data, this article discusses the epidemiology, pathogenesis, treatment and management strategies, and future prospects of MAFLD-ACLF.
- Metabolic Associated Fatty Liver Disease /
- Acute-On-Chronic Liver Failure /
- Liver Transplantation

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参考文献(34)

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