叉头转录因子家族在肝细胞癌中的作用机制及其作为治疗靶点的前景

李恬雨; 闫会敏

doi:10.3969/j.issn.1001-5256.2021.04.044

叉头转录因子家族在肝细胞癌中的作用机制及其作为治疗靶点的前景

DOI: 10.3969/j.issn.1001-5256.2021.04.044

李恬雨¹,
闫会敏^{1, 2, ,}

1.
河北医科大学公共卫生学院流行病与卫生统计学教研室，石家庄 050017
2.
石家庄市第五医院研究所，石家庄 050021

基金项目:

河北省医学适用技术跟踪项目 (GZ2020071)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李恬雨负责资料分析，撰写及修改论文；闫会敏负责拟定写作思路，修改论文并最后定稿。

详细信息

作者简介:
李恬雨(1994—)，女，主要从事肝癌相关基因组学研究

通信作者:
闫会敏，yanhm_2538@163.com

中图分类号: R735.7
计量
- 文章访问数: 514
- HTML全文浏览量: 216
- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2020-09-18
- 录用日期: 2020-11-05
- 出版日期: 2021-04-20

Mechanism of action of forkhead box transcription factors in hepatocellular carcinoma and their prospects as treatment targets

Tianyu LI¹,
Huimin YAN^{1, 2
, ,}

1.
Department of Epidemiology and Health Statistics, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China
2.
Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China

摘要

摘要: 肝细胞癌(HCC)是最常见的恶性癌症之一，发病率和病死率一直居高不下，预后很差。叉头框(FOX)转录因子家族可调控细胞的生长、分化及组织发育，在肿瘤中具有重要的生物学作用。综述了FOX家族分子表达与HCC发生发展及预后的关系，分析了FOX在HCC进展中发挥作用的机制，提出FOX家族分子有望成为HCC治疗的新靶点。
- 癌, 肝细胞 /
- 叉头转录因子类 /
- 癌基因 /
- 基因, 肿瘤抑制
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant cancers and has high incidence and mortality rates and poor prognosis. Forkhead box (FOX) transcription factor family can regulate cell growth, differentiation, and tissue development and plays an important role in tumor. This article reviews the association of the molecular expression of the FOX family with the development, progression, and prognosis of HCC and analyzes the mechanism of action of FOX in the progression of HCC. It is pointed out that FOX family is expected to become a new target for HCC treatment.
- Carcinoma, Hepatocellular /
- Forkhead Transcription Factors /
- Oncogenes /
- Genes, Tumor Suppressor

HTML全文

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