非酒精性脂肪性肝病代谢组学研究进展

栾雨婷; 黄钟鸣; 沈文娟; 哈明昊; 顼志兵

doi:10.3969/j.issn.1001-5256.2021.04.047

非酒精性脂肪性肝病代谢组学研究进展

DOI: 10.3969/j.issn.1001-5256.2021.04.047

上海中医药大学附属第七人民医院感染性疾病科，上海 200137

基金项目:

上海中医药大学附属第七人民医院人才培养计划 (XX2019-17)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：栾雨婷负责撰写修改论文；黄钟鸣、沈文娟、哈明昊负责参与文献的收集、整理；顼志兵负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
栾雨婷(1990—)，女，主要从事慢性肝病的基础与临床研究

通信作者:
顼志兵，xzb6160@163.com

中图分类号: R575.5
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- 被引次数: 0
出版历程
- 收稿日期: 2020-11-06
- 录用日期: 2020-12-17
- 出版日期: 2021-04-20

Research advances in metabolomics in nonalcoholic fatty liver disease

Department of Infectious Diseases, The Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)发病率逐渐升高，已成为我国第一大慢性肝病的首要原因。目前对NAFLD的发病机制并未完全阐明且无特效药物。从发病机制、无创诊断、药物作用与疗效角度出发，介绍了以机体内源性小分子代谢物为研究对象的代谢组学在NAFLD中的研究进展，为进一步探索NAFLD提供新的思路与方法。
- 非酒精性脂肪性肝病 /
- 代谢组学 /
- 诊断
Abstract: The incidence rate of nonalcoholic fatty liver disease (NAFLD) is gradually increasing, and NAFLD has become the most important chronic liver disease in China. At present, the pathogenesis of NAFLD has not been fully elucidated and there are still no effective drugs. From the perspectives of pathogenesis, noninvasive diagnosis, and drug action and efficacy, this article introduces the research advances in metabolomics regarding endogenous small molecule metabolites in NAFLD, so as to provide new ideas and methods for further exploration of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Metabolomics /
- Diagnosis

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参考文献(38)

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