Kupffer细胞在原发性胆汁性胆管炎发生发展中的作用

付海艳; 唐映梅

doi:10.3969/j.issn.1001-5256.2021.04.051

Kupffer细胞在原发性胆汁性胆管炎发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.04.051

付海艳,
唐映梅^,

昆明医科大学第二附属医院消化内科，昆明 650000

基金项目:

国家自然科学基金资助项目 (81360072);

国家自然科学基金资助项目 (8176030241);

国家自然科学基金资助项目 (8166030160)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：付海艳负责查阅文献，撰写论文；唐映梅负责修改文章并最后定稿。

详细信息

作者简介:
付海艳(1985—)，女，主要从事慢性肝病基础研究

通信作者:
唐映梅，tangyingmei_med@kmmu.edu.cn

中图分类号: R575.22
计量
- 文章访问数: 645
- HTML全文浏览量: 126
- PDF下载量: 36
- 被引次数: 0
出版历程
- 收稿日期: 2020-10-08
- 录用日期: 2020-12-03
- 出版日期: 2021-04-20

Role of Kupffer cells in the development and progression of primary biliary cholangitis

Haiyan FU,
Yingmei TANG^,

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

摘要

摘要: 原发性胆汁性胆管炎(PBC)发病率逐年增加，但目前尚无特效药物，发病机制复杂。Kupffer细胞作为调节免疫的关键细胞，在PBC中的作用不容忽视。肝细胞受损时，Kupffer细胞被激活，释放大量炎症因子和趋化因子，参与PBC的发生发展。从Kupffer细胞在PBC中的作用进行简要阐述和分析，为Kupffer细胞作为PBC治疗的可能靶点提供部分理论依据。
- 肝硬化，胆汁性 /
- Kupffer细胞 /
- 炎症 /
- 氧化应激
Abstract: The incidence rate of primary biliary cholangitis (PBC) is increasing year by year, but there is still no specific medicine at present and PBC has a complex pathogenesis. Kupffer cells, as the key cells involved in immunoregulation, play an important role in PBC. When hepatocytes are damaged, Kupffer cells will be activated and release a large amount of inflammatory cytokines and chemokines, which participate in the development and progression of PBC. This article briefly reviews the role of Kupffer cells in PBC, so as to provide a theoretical basis for Kupffer cells as a potential target for the treatment of PBC.
- Liver Cirrhosis, Biliary /
- Kupffer Cells /
- Inflammation /
- Oxidative Stress

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