淋巴细胞活化基因3在肝脏相关疾病中的研究进展

陈锐; 王志鑫; 樊海宁; 王海久

doi:10.3969/j.issn.1001-5256.2021.04.056

淋巴细胞活化基因3在肝脏相关疾病中的研究进展

DOI: 10.3969/j.issn.1001-5256.2021.04.056

青海大学附属医院肝胆胰外科，青海省包虫病重点实验室，西宁 810001

基金项目:

青海省科技厅重大科技专项 (2016-SF-A5);

青海省包虫病研究重点实验室 (2020-ZJ-Y01);

中科院“西部之光”青年学者项目 ;

青海“高端创新人才千人计划”培养拔尖人才项目

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：陈锐负责拟定写作思路，撰写论文；王志鑫负责资料收集及分析，修改论文；樊海宁、王海久指导撰写文章并最后定稿。

详细信息

作者简介:
陈锐(1994—)，男，主要从事肝胆胰疾病及包虫病诊治方面的研究

通信作者:
王海久，yjsgp@sina.cn

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2020-10-01
- 录用日期: 2020-12-26
- 出版日期: 2021-04-20

Research advances in the role of lymphocyte activation gene-3 in liver-related diseases

Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qinghai University, Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China

Research funding:

(2016-SF-A5);

(2020-ZJ-Y01);

;

摘要

摘要: 免疫检查点抑制剂疗法在恶性肿瘤及传染性疾病的治疗中显现出广阔的前景，但应用过程中暴露出的问题驱使研究者探索潜在的免疫检查点。总结了新型免疫检查点淋巴细胞活化基因3在肝脏相关疾病中的研究进展，旨在为后续研究提供参考。淋巴细胞活化基因3有望成为下一代免疫检查点抑制剂疗法的经典靶点，在肝脏相关疾病的免疫治疗中发挥关键作用。
- 肝疾病 /
- 免疫抑制法 /
- 治疗学
Abstract: Immune checkpoint inhibitors (ICIs) therapy has shown broad prospects in the treatment of malignant tumors and infectious diseases, but problems encountered during application drive researchers to explore potential immune checkpoints. This article summarizes the research advances in the role of the new immune checkpoint lymphocyte activation gene-3 (LAG-3) in liver-related diseases, aiming to provide a reference for subsequent research. LAG-3 is expected to become the classic target of next-generation ICIs therapy and play a key role in immunotherapy for liver-related diseases.
- Liver Diseases /
- Immunosuppression /
- Therapeutics

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参考文献(51)

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