继发于胰腺癌的胰腺外分泌功能不全的研究进展
DOI: 10.3969/j.issn.1001-5256.2021.04.057
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:史晨光负责相关文献资料的收集、分析及论文初稿的写作; 刘晓欢、谢亚兴参与文献资料的分析和整理;马艳波负责构思并拟定写作思路,指导论文的写作并最终定稿。
Research advances in pancreatic exocrine insufficiency secondary to pancreatic cancer
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摘要: 目前国际上对胰腺外分泌功能不全的诊断和治疗标准尚未完善,胰腺外科医师对继发于胰腺癌的胰腺外分泌功能不全常常忽视或错误估计,使得胰腺外分泌功能不全未得到充分治疗,严重影响了胰腺癌患者的生存质量。对胰腺癌患者胰腺外分泌功能不全的发病机制、典型症状、诊断方法、不同胰腺癌阶段的胰酶替代治疗等方面的最新研究进展进行了归纳总结, 分析认为胰酶替代治疗能显著改善不同疾病阶段胰腺癌患者的生存质量。Abstract: At present, there is still a lack of comprehensive diagnosis and treatment criteria for pancreatic exocrine insufficiency around the world. Pancreatic surgeons often ignore or misjudge pancreatic exocrine insufficiency secondary to pancreatic cancer, and as a result, pancreatic exocrine insufficiency is not adequately treated, which greatly affects the quality of life of patients with pancreatic cancer. This article summarizes the latest research advances in the pathogenesis, typical symptoms, and diagnostic methods of pancreatic exocrine insufficiency, as well as pancreatic enzyme replacement therapy in different stages of pancreatic cancer. It is pointed out that pancreatic enzyme replacement therapy can significantly improve the quality of life of patients with different stages of pancreatic cancer.
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