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慢性HBV感染免疫耐受期患者应精准抗病毒治疗

李婷婷 姜艳芳

引用本文:
Citation:

慢性HBV感染免疫耐受期患者应精准抗病毒治疗

DOI: 10.3969/j.issn.1001-5256.2021.05.006
详细信息
    作者简介:

    李婷婷(1993—),女,主要从事免疫和基因检测技术及转化研究

    通信作者:

    姜艳芳,yanfangjiang@hotmail.com

  • 中图分类号: R512.62

Patients in the immune-tolerant phase of chronic HBV infection should be precisely treated with antiviral therapy

  • [1] FUNG J, SETO WK, LAI CL, et al. Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: Implications for antiviral therapy[J]. J Hepatol, 2011, 54(2): 195-200. DOI: 10.1016/j.jhep.2010.06.031.
    [2] LEE HA, LEE HW, KIM IH, et al. Extremely low risk of hepatocellular carcinoma development in patients with chronic hepatitis B in immune-tolerant phase[J]. Aliment Pharmacol Ther, 2020, 52(1): 196-204. DOI: 10.1111/apt.15741.
    [3] CHAO DT, LIM JK, AYOUB WS, et al. Systematic review with meta-analysis: The proportion of chronic hepatitis B patients with normal alanine transaminase≤40 IU/L and significant hepatic fibrosis[J]. Aliment Pharmacol Ther, 2014, 39(4): 349-358. DOI: 10.1111/apt.12590.
    [4] KENNEDY P, SANDALOVA E, JO J, et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B[J]. Gastroenterology, 2012, 143(3): 637-645. DOI: 10.1053/j.gastro.2012.06.009.
    [5] KENNEDY P, SANDALOVA E, JO J, et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B[J]. Gastroenterology, 2012, 143(3): 637-645. DOI: 10.1053/j.gastro.2012.06.009.
    [6] PÉNEAU C, IMBEAUD S, LA BELLA T, et al. Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma[J]. Gut, 2021. DOI: 10.1136/gutjnl-2020-323153.[Online ahead of print]
    [7] YIP TC, WONG GL, WONG VW. Negligible risk of HCC in chronic hepatitis B patients in immune-tolerant phase: Myth or fact[J]. Clin Mol Hepatol, 2021. DOI: 10.3350/cmh.2021.0019.[Online ahead of print]
    [8] KIM HL, KIM GA, PARK JA, et al. Cost-effectiveness of antiviral treatment in adult patients with immune-tolerant phase chronic hepatitis B[J]. Gut, 2020. DOI: 10.1136/gutjnl-2020-321309.[Online ahead of print]
    [9] JENG WJ, LOK AS. Should treatment indications for chronic hepatitis B be expanded?[J]. Clin Gastroenterol Hepatol, 2020. DOI: 10.1016/j.cgh.2020.04.091.[Online ahead of print]
    [10] LI J, ZOU B, YEO YH, et al. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: A systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol, 2019, 4(5): 389-398. DOI: 10.1016/S2468-1253(19)30039-1.
    [11] TOUT I, LOUREIRO D, MANSOURI A, et al. Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development[J]. J Hepatol, 2020, 73(2): 409-422. DOI: 10.1016/j.jhep.2020.04.013.
    [12] HSU YC, HUANG YT. Editorial: Risk assessment for chronic hepatitis B patients in the immune tolerant phase-both definition and selection matter[J]. Aliment Pharmacol Ther, 2020, 52(1): 213-214. DOI: 10.1111/apt.15798.
    [13] SHARIF A, ABBAS Z, AHMED S, et al. Effect of non-alcoholic fatty liver disease on transaminase levels and transient elastography in patients with chronic hepatitis B[J]. Cureus, 2019, 11(10): e5995. DOI: 10.7759/cureus.5995.
    [14] SONNEVELD MJ, BROUWER WP, HANSEN BE, et al. Very low probability of significant liver inflammation in chronic hepatitis B patients with low ALT levels in the absence of liver fibrosis[J]. Aliment Pharmacol Ther, 2020, 52(8): 1399-1406. DOI: 10.1111/apt.16067.
    [15] van CAMPENHOUT M, van BÖMMEL F, PFEFFERKORN M, et al. Host and viral factors associated with serum hepatitis B virus RNA levels among patients in need for treatment[J]. Hepatology, 2018, 68(3): 839-847. DOI: 10.1002/hep.29872.
    [16] SCHOEMAN JC, HOU J, HARMS AC, et al. Metabolic characterization of the natural progression of chronic hepatitis B[J]. Genome Med, 2016, 8(1): 64. DOI: 10.1186/s13073-016-0318-8.
    [17] MCMAHON BJ. The natural history of chronic hepatitis B virus infection[J]. Hepatology, 2009, 49(5 Suppl): s45-s55. DOI: 10.1002/hep.22898.
    [18] TEBANI A, GUMMESSON A, ZHONG W, et al. Integration of molecular profiles in a longitudinal wellness profiling cohort[J]. Nat Commun, 2020, 11(1): 4487. DOI: 10.1038/s41467-020-18148-7.
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出版历程
  • 收稿日期:  2021-02-23
  • 录用日期:  2021-03-31
  • 出版日期:  2021-05-20
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