IL-1β在酒精性肝病发病机制中的作用

全卉; 江宇泳

doi:10.3969/j.issn.1001-5256.2021.05.053

IL-1β在酒精性肝病发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2021.05.053

全卉^{1, 2},
江宇泳^1, ,

1.
首都医科大学附属北京地坛医院中西医结合中心，北京 100011
2.
北京中医药大学研究生院，北京 100011

基金项目:

北京中医药科技基金 (JJ2018-44);

首都卫生发展基金 (首发2020-2-2172)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：全卉负责查找文献，资料分析，撰写论文；江宇泳负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
全卉(1996—)，女，主要从事肝脏疾病相关研究

通信作者:
江宇泳，jyuy11@126.com

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2020-10-11
- 录用日期: 2020-12-14
- 出版日期: 2021-05-20

Role of interleukin-1β in the pathogenesis of alcoholic liver disease

Hui QUAN^{1, 2},
Yuyong JIANG^{1
, ,}

1.
Department of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100011, China
2.
Graduate School of Beijing University of Chinese Medicine, Beijing100011, China

摘要

摘要: 酒精性肝病(ALD)已成为我国仅次于病毒性肝病的第二大肝病，慢性酒精暴露增加了IL-1β等促炎因子的产生，其与酒精性肝炎的主要症状如发热、白细胞增加密切相关。介绍了IL-1β的产生和功能；在ALD中通过对肝实质细胞与非实质细胞的作用推进肝脂肪变性和炎症，通过调控肝星状细胞的增殖来加速肝纤维化，指出通过干扰IL-1β的途径可能成为未来治疗ALD的策略之一。
- 肝疾病, 酒精性 /
- 脂肪肝, 酒精性 /
- 白细胞介素1β
Abstract: Alcoholic liver disease (ALD) has become the second largest liver disease after viral liver disease in China. Chronic alcohol exposure increases the production of proinflammatory factors including interleukin-1β (IL-1β), which is closely associated with the main symptoms of alcoholic hepatitis such as pyrexia and elevated white blood cell count. This article introduces the production and function of IL-1β; in ALD, it promotes hepatic steatosis and inflammation by acting on liver parenchymal cells and nonparenchymal cells and accelerates liver fibrosis by regulating the proliferation of hepatic stellate cells. It is pointed out that interference with the IL-1β pathway may become one of the treatment strategies for ALD in the future.
- Liver Diseases, Alcoholic /
- Fatty Liver, Alcoholic /
- Interleukin-1beta

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参考文献(35)

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