非酒精性脂肪性肝炎新药研发：一个未被满足的临床需求

何忆宁; 施军平

doi:10.3969/j.issn.1001-5256.2021.06.001

非酒精性脂肪性肝炎新药研发：一个未被满足的临床需求

DOI: 10.3969/j.issn.1001-5256.2021.06.001

何忆宁¹,
施军平^{1, 2, ,}

1.
杭州师范大学医学部临床医学院，杭州 310018
2.
杭州师范大学附属医院肝病科，杭州 310014

基金项目:

杭州市重大科技计划项目 (20172016A03)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：何忆宁负责完成述评初稿撰写；施军平负责设计文章思路，初稿修订，审核及定稿。

详细信息

作者简介:
何忆宁(1996—)，女，主要从事非酒精性脂肪性肝病的临床研究

通信作者:
施军平，20131004@hznu.edu.cn

中图分类号: R575.5
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- 文章访问数: 745
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- 被引次数: 0
出版历程
- 收稿日期: 2021-05-04
- 录用日期: 2021-05-04
- 出版日期: 2021-06-20

Research and development of new drugs for nonalcoholic steatohepatitis: An unmet need in clinical practice

Yining HE¹,
Junping SHI^{1, 2
, ,}

1.
School of Clinical Medicine, Hangzhou Normal University Medical College, Hangzhou 310018, China
2.
Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310014, China

摘要

摘要: 随着全球范围内病毒性肝炎得到有效控制，非酒精性脂肪性肝炎(NASH)在未来10年将成为肝移植的主要病因。NASH患者数量庞大，但至今尚无任何权威机构批准的治疗药物上市，这代表着一个巨大的尚未满足的临床需求。NASH复杂的发病机制、疾病异质性、诊断障碍以及治疗终点的选择等给新药研发带来了巨大挑战。
- 非酒精性脂肪性肝病 /
- 药物发现 /
- 临床试验
Abstract: With the effective control of viral hepatitis around the world, nonalcoholic steatohepatitis (NASH) will become the main cause of liver transplantation in the next ten years. There is a huge number of NASH patients, but currently no drug has been approved by authorities, which represents a large unmet need in clinical practice. The complex pathogenesis of NASH, heterogeneity of this disease, difficulties in diagnosis, and selection of treatment endpoints have brought great challenges to the research and development of new drugs.
- Non-alcoholic Fatty Liver Disease /
- Drug Discovery /
- Clinical Trial

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参考文献(22)

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