ALT正常、HBeAg阳性慢性HBV感染者如何选择合适的治疗时机?
DOI: 10.3969/j.issn.1001-5256.2021.06.012
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作者贡献声明:赵红负责起草文章; 谢雯负责文章修改和审校。
How to determine the optimal treatment timing in chronic HBV infection patients with normal ALT and positive HBeAg?
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Key words:
- Hepatitis B Virus /
- Hepatitis B, Chronic /
- Immune Tolerance /
- Therapeutics
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[1] CHEN CJ, YANG HI, SU J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level[J]. JAMA, 2006, 295(1): 65-73. DOI: 10.1001/jama.295.1.65. [2] KIM GA, LIM YS, HAN S, et al. High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B[J]. Gut, 2018, 67(5): 945-952. DOI: 10.1136/gutjnl-2017-314904. [3] LEE HW, KIM EH, LEE J, et al. Natural history of untreated HBeAg-positive chronic HBV infection with persistently elevated HBV DNA but normal alanine aminotransferase[J]. Clin Transl Gastroenterol, 2020, 11(3): e00140. DOI: 10.14309/ctg.0000000000000140. [4] CHANG Y, CHOE WH, SINN DH, et al. Nucleos(t)ide analogue treatment for patients with hepatitis B virus (HBV) e antigen-positive chronic HBV genotype C infection: A nationwide, multicenter, retrospective study[J]. J Infect Dis, 2017, 216(11): 1407-1414. DOI: 10.1093/infdis/jix506.
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