肝癌微环境对髓源性抑制细胞的影响

李雪艳; 王昌俊

doi:10.3969/j.issn.1001-5256.2021.06.053

肝癌微环境对髓源性抑制细胞的影响

DOI: 10.3969/j.issn.1001-5256.2021.06.053

李雪艳^{1, 2},
王昌俊^2, ,

1.
南方医科大学中医药学院，广州 510000
2.
广东省人民医院中医科，广东省医学科学院，广东省老年医学研究所，广州 510000

基金项目:

国家自然科学基金 (81774261)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李雪艳负责论文构思和撰写；李雪艳、王昌俊参与论文修改；李雪艳拟定写作思路，撰写文章并最后定稿。

详细信息

作者简介:
李雪艳(1997—)，女，主要从事肝癌方面研究

通信作者:
王昌俊，gzwchj@126.com

中图分类号: R735.7
计量
- 文章访问数: 460
- HTML全文浏览量: 219
- PDF下载量: 43
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-17
- 录用日期: 2021-01-05
- 出版日期: 2021-06-20

Influence of hepatocellular carcinoma microenvironment on myeloid-derived suppressor cells

Xueyan LI^{1, 2},
Changjun WANG^{2
, ,}

1.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, China
2.
Department of TCM, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Institute of Geriatrics, Guangzhou 510000, China

摘要

摘要: 髓源性抑制细胞(MDSC)是一群具有免疫抑制作用的未成熟骨髓细胞，其大量存在于肿瘤患者体内，诱导肿瘤细胞逃脱免疫细胞的杀伤，促进肿瘤的发生、进展、转移。近年来，其在肝癌微环境中的作用受到广泛关注，但其在肝癌微环境中募集、分化的相关机制仍未有清晰的阐述。主要总结了肝癌微环境中的肿瘤细胞和肿瘤基质细胞如肝星状细胞、肿瘤相关成纤维细胞、肿瘤相关内皮细胞等对MDSC分化、募集的作用机制，提出靶向MDSC作为辅助疗法以增强肝癌免疫治疗的潜在价值。
- 癌, 肝细胞 /
- 肿瘤微环境 /
- 髓源性抑制细胞 /
- 肝星状细胞
Abstract: Myeloid-derived suppressor cells (MDSCs) are a group of immature bone marrow cells with an immunosuppressive effect, and they are abundant in tumor patients and can induce tumor cells to escape the killing of immune cells and thus promote the development, progression, and metastasis of tumor. In recent years, its role in hepatocellular carcinoma microenvironment has attracted more and more attention, but the mechanisms of its recruitment and differentiation in hepatocellular carcinoma microenvironment have not been clearly elucidated. This article mainly summarizes the mechanism of action of tumor cells and tumor stromal cells in hepatocellular carcinoma microenvironment (such as hepatic stellate cells, tumor-associated fibroblasts, and tumor-associated endothelial cells) in the recruitment and differentiation of MDSCs, and it is proposed to target MDSCs as an adjuvant therapy to enhance the potential value of immunotherapy for liver cancer.
- Carcinoma, Hepatocellular /
- Tumor Microenvironment /
- Myeloid-Derived Suppressor Cells /
- Hepatic Stellate Cells

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参考文献(37)

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