免疫治疗在肝细胞癌中的应用价值

邹燕梅; 袁响林

doi:10.3969/j.issn.1001-5256.2021.08.004

免疫治疗在肝细胞癌中的应用价值

DOI: 10.3969/j.issn.1001-5256.2021.08.004

邹燕梅,
袁响林^,

华中科技大学同济医学院附属同济医院肿瘤科，武汉 430030

基金项目:

国家自然科学基金青年科学基金项目 (81773231)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：邹燕梅负责收集数据，资料分析，撰写论文；袁响林负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
袁响林，yuanxianglin@hust.edu.cn

中图分类号: R735.7
计量
- 文章访问数: 771
- HTML全文浏览量: 203
- PDF下载量: 168
- 被引次数: 0
出版历程
- 收稿日期: 2021-05-28
- 录用日期: 2021-05-28
- 出版日期: 2021-08-20

Application value of immunotherapy in hepatocellular carcinoma

Yanmei ZOU,
Xianglin YUAN^,

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Research funding:

National Natural Science Foundation of China Young Scientist Fund (81773231)

摘要

摘要: 免疫治疗为肝细胞癌(HCC)患者迎来了曙光。目前HCC单用免疫治疗药物已初显疗效，靶向和免疫联合治疗方案在HCC转化治疗、围术期治疗中展现了巨大潜力，探讨HCC靶向免疫治疗，以及治疗评价、预测体系和安全性等问题，系统阐述免疫治疗在HCC中的应用价值及未来的探索方向。
- 癌, 肝细胞 /
- 免疫疗法
Abstract: Immunotherapy has brought new hope for hepatocellular carcinoma (HCC) patients. At present, immunotherapy drugs alone have achieved a certain therapeutic effect in the treatment of HCC, and combined treatment regimen of targeted therapy and immunotherapy has shown great potential in the conversion therapy and perioperative treatment for HCC. This article discusses targeted immunotherapy for HCC and related issues in treatment evaluation, prediction system, and safety and further elaborates on the application value of immunotherapy in HCC and the directions for further exploration.
- Carcinoma, Hepatocellular /
- Immunotherapy

HTML全文

参考文献(15)

[1]	SUNG H, FERLAY J, SIEGEL RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI: 10.3322/caac.21660.
[2]	ZHENG RS, SUN KX, ZHANG SW, et al. Report of cancer epidemiology in China, 2015[J]. Chin J Oncol, 2019, 41(1): 19-28. DOI: 10.3760/cma.j.issn.0253-3766.2019.01.008. 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2019, 41(1): 19-28. DOI: 10.3760/cma.j.issn.0253-3766.2019.01.008.
[3]	Guidelines Working Committee of Chinese Society of Clinical Oncology. Guidelines for the diagnosis and treatment of primary liver cancer (2020 edition)[M]. Beijing: People's Medical Publishing House, 2020. 中国临床肿瘤学会指南工作委员会. 原发性肝癌诊疗指南2020[M]. 北京: 人民卫生出版社, 2020.
[4]	EL-KHOUEIRY AB, SANGRO B, YAU T, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial[J]. Lancet, 2017, 389(10088): 2492-2502. DOI: 10.1016/S0140-6736(17)31046-2.
[5]	FINN RS, RYOO BY, MERLE P, et al. Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: A randomized, double-blind, phase Ⅲ trial[J]. J Clin Oncol, 2020, 38(3): 193-202. DOI: 10.1200/JCO.19.01307.
[6]	QIN S, REN Z, MENG Z, et al. Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: A multicentre, open-label, parallel-group, randomised, phase 2 trial[J]. Lancet Oncol, 2020, 21(4): 571-580. DOI: 10.1016/S1470-2045(20)30011-5.
[7]	YAU T, PARK JW, FINN RS, et al. LBA38_PR-CheckMate 459: A randomized, multi-center phase Ⅲ study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC)[J]. Ann Oncol, 2019, 30(Suppl 5): v874-v875.
[8]	KUDO M, IKEDA M, MOTOMURA K, et al. A phase Ib study of lenvatinib (LEN) plus nivolumab (NIV) in patients (pts) with unresectable hepatocellular carcinoma (uHCC): Study 117[J]. J Clin Oncol, 2020, 38(4_suppl): 513. DOI: 10.1200/JCO.2020.38.4_suppl.513.
[9]	FINN RS, QIN S, IKEDA M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma[J]. N Engl J Med, 2020, 382(20): 1894-1905. DOI: 10.1056/NEJMoa1915745.
[10]	XU J, SHEN J, GU S, et al. Camrelizumab in combination with apatinib in patients with advanced hepatocellular carcinoma (RESCUE): A nonrandomized, open-label, phase Ⅱ trial[J]. Clin Cancer Res, 2021, 27(4): 1003-1011. DOI: 10.1158/1078-0432.CCR-20-2571.
[11]	SUN HC, ZHU XD, HUANG C, et al. Combination therapy with lenvatinib and anti-PD-1 antibodies for unresectable or advanced hepatocellular carcinoma: A real-world study[J]. J Clin Oncol, 2020, 38(15_suppl): e16610. DOI: 10.1200/JCO.2020.38.15_suppl.e16610.
[12]	KOROKI K, KANOGAWA N, MARUTA S, et al. Posttreatment after lenvatinib in patients with advanced hepatocellular carcinoma[J]. Liver Cancer, 2021. [Online ahead of print] DOI: 10.1159/000515552.
[13]	EXPOSITO MJJ, AKCE M, ALVAREZ JLM, et al. 209TiP-CA209-9DX: Phase Ⅲ, randomized, double-blind study of adjuvant nivolumab vs placebo for patients with hepatocellular carcinoma (HCC) at high risk of recurrence after curative resection or ablationp[J]. Ann Oncol, 2018, 29(Suppl 9): ix65.
[14]	KUDO M, MOTOMURA K, WADA Y, et al. Avelumab in combination with axitinib as first-line treatment in patients with advanced hepatocellular carcinoma: Results from the phase 1b VEGF liver 100 trial[J]. Liver Cancer, 2021, 10(3): 249-259. DOI: 10.1159/000514420.
[15]	PINTER M, JAIN RK, DUDA DG. The current landscape of immune checkpoint blockade in hepatocellular carcinoma: A review[J]. JAMA Oncol, 2021, 7(1): 113-123. DOI: 10.1001/jamaoncol.2020.3381.