聚乙二醇干扰素治疗慢性乙型肝炎致1型糖尿病1例报告
DOI: 10.3969/j.issn.1001-5256.2021.08.031
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张婷婷负责资料分析,随访患者,撰写论文;赵珏参与查阅文献;杨彦、康姚洁负责拟定写作思路;王煊指导撰写文章并最后定稿。
Type 1 diabetes mellitus due to pegylated interferon treatment of chronic hepatitis B: A case report
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Key words:
- Hepatitis B, Chronic /
- Interferons /
- Diabetes Mellitus, Type 1
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表 1 患者口服葡萄糖耐量试验结果(75 g)
时间 2019年10月6日 2020年1月4日 血糖(mmol/L) 胰岛素(μIU/ml) C肽(ng/ml) 血糖(mmol/L) 胰岛素(μIU/ml) C肽(ng/ml) 0 21.5 1.4 0.56 5.2 2.41 0.57 60 min 13.7 10.32 1.64 120 min 32.2 1.4 0.54 11.0 18.43 3.37 -
[1] FABRIS P, BETTERLE C, FLOREANI A, et al. Development of type 1 diabetes mellitus during interferon alfa therapy for chronic HCV hepatitis[J]. Lancet, 1992, 340: 548. DOI: 10.1016/0140-6736(92)91744-s. [2] NEGRO F. Adverse effects of drugs in the treatment of viral hepatitis[J]. Best Pract Res Clin Gastroenterol, 2010, 24(2): 183-192. DOI: 10.1016/j.bpg.2009.10.012. [3] ZORNITZKI T, MALNICK S, LYSYY L, et al. Interferon therapy in hepatitis C leading to chronic type 1 diabetes[J]. World J Gastroenterol, 2015, 21(1): 233-239. DOI: 10.3748/wjg.v21.i1.233. [4] WAGURI M, HANAFUSA T, ITOH N, et al. Occurrence of IDDM during interferon therapy for chronic viral hepatitis[J]. Diabetes Res Clin Pract, 1994, 23(1): 33-26. DOI: 10.1016/0168-8227(94)90124-4. [5] SUKRAN K, GOZAYDIN A, AKKOCLU G, et al. Chronic hepatitis B with type I diabetes mellitus and autoimmune thyroiditis development during interferon alpha therapy[J]. Infect Dev Ctries, 2012, 6(4): 364-368. DOI: 10.3855/jidc.1632. [6] LV Y, SHI BY, GUO H. Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B[J]. World J Gastroenterol, 2008, 14(29): 4713-4715. DOI: 10.3748/wjg.14.4713.
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