原发性肝淋巴瘤伴贫血和低蛋白血症1例报告

李伟锋; 吴帆

doi:10.3969/j.issn.1001-5256.2021.08.034

原发性肝淋巴瘤伴贫血和低蛋白血症1例报告

DOI: 10.3969/j.issn.1001-5256.2021.08.034

李伟锋,
吴帆^,

暨南大学附属广州红十字会医院肝胆外科，广州 510220

基金项目:

国家自然科学基金面上项目 (81974442);

广东省自然科学基金面上项目 (2020A1515010799)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李伟锋负责课题设计，资料分析，撰写论文，修改论文; 吴帆负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
吴帆，wufan7911@ext.jnu.edu.cn

中图分类号: R735.7
计量
- 文章访问数: 524
- HTML全文浏览量: 92
- PDF下载量: 30
- 被引次数: 0
出版历程
- 收稿日期: 2020-12-26
- 录用日期: 2021-01-25
- 出版日期: 2021-08-20

Primary hepatic lymphoma with anemia and hypoproteinemia: A case report

Weifeng LI,
Fan WU^,

Department of Hepatobiliary Surgery, Guangzhou Red Cross Hospital Affiliated to Jinan University, Guangzhou 510220, China

Research funding:

General Project of National Natural Science Foundation of China (81974442);

General Project of Natural Science Foundation of Guangdong Province (2020A1515010799)

摘要

- 淋巴瘤, 非霍奇金 /
- 贫血 /
- 低蛋白血症
- Lymphoma, Non-Hodgkin /
- Anemia /
- Hypoproteinemia

HTML全文

图 1 上腹增强CT

注：a，CT平扫肿物呈低密度，密度均匀; b，CT增强呈轻度强化; c，CT门静脉期强化轻度上升，强化程度均低于正常肝组织。图中箭头所示为肝脏肿物。

下载: 全尺寸图片幻灯片

图 2 上腹MRI

注：a，T₁WI呈低信号; b，T₂WI呈稍高信号，信号不均匀。图中箭头所示为肝脏肿物。

下载: 全尺寸图片幻灯片

图 3 肝S4段手术切除标本

下载: 全尺寸图片幻灯片

图 4 肝S4段病理切片(HE染色，×300)

注：图中圈出部分可见较多肿瘤细胞集聚，肿瘤细胞浸润性生长，肿瘤细胞圆形，体积中等偏小，细胞核部分空亮，核染色质排列在核膜周边，部分细胞核深染，扭曲。

下载: 全尺寸图片幻灯片

参考文献(12)

[1]	MEHTA N, JAYAPAL L, GONEPPANAVAR M, et al. Primary hepatic lymphoma: A rare case report[J]. JGH Open, 2019, 3(3): 261-263. DOI: 10.1002/jgh3.12131.
[2]	WANG MS, WANG XG, ZHENG JF, et al. Primary hepatic diffuse large B-cell lymphoma: A report of five cases and literature review[J]. J Chongqing Med Univ, 2016, 41(6): 605-608. DOI: 10.13406/j.cnki.cyxb.000947. 王木森, 王新国, 郑金锋, 等. 原发性肝脏弥漫大B细胞淋巴瘤5例报道并文献复习[J]. 重庆医科大学学报, 2016, 41(6): 605-608. DOI: 10.13406/j.cnki.cyxb.000947.
[3]	LI BG, YAN YH, XIAO JS, et al. A case of primary liver diffuse large B cell lymphoma[J]. Chin J Gen Surg, 2015, 30(3): 255-256. DOI: 10.3760/cma.j.issn.1007-631X.2015.03.026. 李包根, 鄢业鸿, 肖建生, 等. 原发性肝脏弥漫性大B细胞淋巴瘤一例[J]. 中华普通外科杂志, 2015, 30(3): 255-256. DOI: 10.3760/cma.j.issn.1007-631X.2015.03.026.
[4]	JI HX, CUI LJ, SIMA H, et al. Primary hepatic lymphoma misdiagnosed as hepatic hemangioma: A case report and domestic literature review[J]. Acad J Second Military Med Univ, 2020, 41(6): 691-696. DOI: 10.16781/j.0258-879x.2020.06.0691. 季鸿翔, 崔龙久, 司马辉, 等. 原发性肝淋巴瘤误诊肝血管瘤1例及国内文献分析[J]. 第二军医大学学报, 2020, 41(6): 691-696. DOI: 10.16781/j.0258-879x.2020.06.0691.
[5]	SHEN J, HAO SG, CHEN BB, et al. A multicenter investigation and analysis on anemia in lymphoma patients in Shanghai[J]. Chin J Hematol, 2020, 41(2): 123-127. DOI: 10.3760/cma.j.issn.0253-2727.2020.02.007. 沈君, 郝思国, 陈波斌, 等. 上海多中心淋巴瘤患者贫血状况调查及分析[J]. 中华血液学杂志, 2020, 41(2): 123-127. DOI: 10.3760/cma.j.issn.0253-2727.2020.02.007.
[6]	ZHAO JZ, ZHOU JY, WANG GF, et al. Expression of interleukin-6 and hepcidin in diffuse large B-cell lymphoma and their relationship with anemia[J]. J Leuk Lymphoma, 2017, 26(1): 37-40, 45. DOI: 10.3760/cma.j.issn.1009-9921.2017.01.012. 赵建治, 周建尧, 王国芳, 等. 白细胞介素6和hepcidin在弥漫大B细胞淋巴瘤中的表达及其与贫血的相关性[J]. 白血病·淋巴瘤, 2017, 26(1): 37-40, 45. DOI: 10.3760/cma.j.issn.1009-9921.2017.01.012.
[7]	TISI MC, BOZZOLI V, GIACHELIA M, et al. Anemia in diffuse large B-cell non-Hodgkin lymphoma: The role of interleukin-6, hepcidin and erythropoietin[J]. Leuk Lymphoma, 2014, 55(2): 270-275. DOI: 10.3109/10428194.2013.802314.
[8]	WANG Y, TANG Y, GUO XL, et al. A case of primary hepatic lymphoma initially presenting as autoimmune hemolytic anemia[J]. J Clin Hepatol, 2018, 34(2): 381-382. DOI: 10.3969/j.issn.1001-5256.2018.02.033. 王燕, 唐杨, 郭晓林, 等. 以自身免疫性溶血性贫血为首发症状的原发肝脏淋巴瘤1例报告[J]. 临床肝胆病杂志, 2018, 34(2): 381-382. DOI: 10.3969/j.issn.1001-5256.2018.02.033.
[9]	JI WG, WANG XQ, LI ZG, et al. Prognostic value of serum β-2microglobulin and lactate dehydrogenase in patients with diffuse large B cell lymphoma[J]. Chin J Gerontol, 2012, 32(18): 3926-3927. DOI: 10.3969/j.issn.1005-9202.2012.18.028. 姬卫国, 王祥麒, 李志刚, 等. 弥漫性大B细胞淋巴瘤患者血清中β-2微球蛋白与乳酸脱氢酶检测对预后判断的价值[J]. 中国老年学杂志, 2012, 32(18): 3926-3927. DOI: 10.3969/j.issn.1005-9202.2012.18.028.
[10]	FENG JY, HU HJ, HUANG B, et al. MRI and CT features of primary hepatic lymphoma[J]. J Chin Clin Med Imaging, 2020, 31(9): 671-674. DOI: 10.12117/jccmi.2020.09.015. 冯结映, 胡海菁, 黄飚, 等. 原发性肝淋巴瘤CT及MRI的影像学表现[J]. 中国临床医学影像杂志, 2020, 31(9): 671-674. DOI: 10.12117/jccmi.2020.09.015.
[11]	YANG XW, TAN WF, YU WL, et al. Diagnosis and surgical treatment of primary hepatic lymphoma[J]. World J Gastroenterol, 2010, 16(47): 6016-6019. DOI: 10.3748/wjg.v16.i47.6016.
[12]	MASTORAKI A, STEFANOU MI, CHATZOGLOU E, et al. Primary hepatic lymphoma: Dilemmas in diagnostic approach and therapeutic management[J]. Indian J Hematol Blood Transfus, 2014, 30(3): 150-154. DOI: 10.1007/s12288-013-0263-2.