酒精性肝病合并肌肉减少症的研究进展

王倩; 常春艳; 杨松

doi:10.3969/j.issn.1001-5256.2021.08.043

酒精性肝病合并肌肉减少症的研究进展

DOI: 10.3969/j.issn.1001-5256.2021.08.043

王倩¹,
常春艳²,
杨松^{2, 3, 4, ,}

1.
解放军联勤保障部队第九六〇医院药学部，济南 250031
2.
首都医科大学附属北京地坛医院肝病中心，北京 100015
3.
北京大学医学部北京地坛医院教学医院肝病中心，北京 100015
4.
青海省第四人民医院肝病二科，西宁 810000

基金项目:

国家科技重大专项 (2017ZX10202202);

国家科技重大专项 (2018ZX10715-005);

青海省高端创新人才千人计划 (2019-24);

中国肝炎防治基金会天晴肝病研究基金 (TQGB20210050)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王倩负责文献检索分析，撰写论文；常春艳参与文献检索及修改论文；杨松负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
杨松，sduyangsong@163.com

中图分类号: R575.5
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- 被引次数: 0
出版历程
- 收稿日期: 2021-01-21
- 录用日期: 2021-02-05
- 出版日期: 2021-08-20

Research advances in alcoholic liver disease with sarcopenia

Qian WANG¹,
Chunyan CHANG²,
Song YANG^{2, 3, 4
, ,}

1.
Department of Pharmacy, 960 Hospital of PLA Joint Logistics Support Force, Jinan 250031, China
2.
Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
3.
Liver Disease Center, Beijing Ditan Teaching Hospital, Peking University Health Science Center, Beijing 100015, China
4.
Second Department of Hepatology, The Forth People's Hospital of Qinghai Province, Xining 810000, China

Research funding:

National Science and Technology Major Project (2017ZX10202202);

National Science and Technology Major Project (2018ZX10715-005);

Qinghai Provincial High-end and Innovative 1000 Talents Plan (2019-24);

Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund (TQGB20210050)

摘要

摘要: 酒精性肝病是影响我国人民健康的主要肝脏疾病之一, 约有60%的酒精性肝病患者合并肌肉减少症。就酒精性肝病发生肌肉减少症的机制而言，除了肝病患者存在食欲下降、营养物质摄入不足、消化吸收障碍、体力活动减少、血氨升高等因素外，酒精及其代谢产物还可作用于多个信号通路影响骨骼肌蛋白合成，促进骨骼肌细胞自噬。酒精性肝病患者合并肌肉减少症发生肝性脑病、肝癌等不良预后风险增加。针对酒精性肝病患者肌肉减少症的干预措施有待深入研究。
- 肝疾病, 酒精性 /
- 肌减少症 /
- 肌, 骨骼
Abstract: Alcoholic liver disease (ALD) is one of the most common liver diseases affecting the health of the Chinese people, and about 60% of ALD patients suffer from sarcopenia. Anorexia, inadequate intake of nutrients, disorder of digestion and absorption, reduction in physical activity, and increase in blood ammonia are common causes of sarcopenia in patients with ALD; besides, alcohol and its metabolites may affect the synthesis of skeletal muscle protein and promote the autophagy of skeletal muscle cells through multiple signaling pathways. Patients with ALD and sarcopenia tend to have increased risks of poor prognosis, such as hepatic encephalopathy and liver cancer. Further studies are needed to investigate the interventions for patients with ALD and sarcopenia.
- Liver Diseases, Alcoholic /
- Sarcopenia /
- Muscle, Skeletal

HTML全文

表 1 2019年AWGS肌少症的诊断标准及临界值

评价维度	评价指标	临界值
评价维度	评价指标	男性	女性
肌力	握力	＜28 kg	＜18 kg
体能表现	6米步行速度	＜1.0 m/s	＜1.0 m/s
	FTSTS	≥12 s	≥12 s
	SPPB	≤9分	≤9分
肌量	ASM(DXA测量)	＜7.0 kg/m²	＜5.4 kg/m²
	ASM(BIA测量)	＜7.0 kg/m²	＜5.7 kg/m²
诊断标准：可能肌少症，肌力下降和/或体能减退；确诊肌少症，肌力下降和/或体能减退+肌量减少；严重肌少症，肌力下降+体能减退+肌量减少
注：FTSTS，5次坐立试验；SPPB，简易机体功能评估法；ASM，四肢肌量；BIA，生物电阻抗测量分析；DXA，双能X线吸收测量。

下载: 导出CSV

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