沉默调节蛋白6在肝脏疾病中的作用及其机制

方欢; 钟晓琳

doi:10.3969/j.issn.1001-5256.2021.08.050

沉默调节蛋白6在肝脏疾病中的作用及其机制

DOI: 10.3969/j.issn.1001-5256.2021.08.050

方欢¹,
钟晓琳^2, ,

1.
西南医科大学临床医学院，四川泸州 646000
2.
西南医科大学附属医院消化内科，四川泸州 646000

基金项目:

四川省科技厅基金项目 (2020YJ0190);

王宝恩肝纤维化研究基金项目 (20200520)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：方欢负责收集资料，分析资料，撰写文章及修改文章；钟晓琳负责拟定写作思路，指导撰写文章，修改文章并最后定稿。

详细信息

通信作者:
钟晓琳，34893230@qq.com

中图分类号: R575; R977.6
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- 文章访问数: 660
- HTML全文浏览量: 176
- PDF下载量: 45
- 被引次数: 0
出版历程
- 收稿日期: 2021-01-04
- 录用日期: 2021-02-10
- 出版日期: 2021-08-20

Role and mechanism of SIRT6 in liver diseases

Huan FANG¹,
Xiaolin ZHONG^{2
, ,}

1.
School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
2.
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

Science and Technology Department Foundation of Sichuan Province (2020YJ0190);

WBE Liver Fibrosis Foundation (20200520)

摘要

摘要: 沉默调节蛋白6(SIRT6)具有去乙酰化酶、单ADP核糖基转移酶以及去脂肪酰化酶等多种功能, 在调控多种生理及病理过程中发挥重要作用。概述了SIRT6的结构及生物学功能，详细介绍了SIRT6在病毒性肝炎、非酒精性脂肪性肝病、酒精性脂肪性肝病、肝硬化、肝癌等不同类型的肝脏疾病中的研究进展及相关作用分子机制。了解SIRT6在肝脏疾病中的作用, 可能为肝病的治疗提供新思路及治疗靶点。
- 乙型肝炎, 慢性 /
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 癌, 肝细胞 /
- 抗衰老酶
Abstract: SIRT6 has the multiple functions of deacetylase, single ADP ribosyltransferase, and defatty acylase and plays an important role in the regulation of various physiological and pathological processes. This article summarizes the structure and biological functions of SIRT6 and introduces in detail the research advances in the role and molecular mechanisms of SIRT6 in different types of liver diseases such as viral hepatitis, nonalcoholic fatty liver, alcoholic fatty liver, liver cirrhosis, and liver cancer. An understanding of the role of SIRT6 in liver diseases may provide new ideas and targets for the treatment of liver diseases.
- Hepatitis B, Chronic /
- Non-Alcoholic Fatty Liver Disease /
- Liver Cirrhosis /
- Carcinoma, Hepatocellular /
- Sirtuins

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