慢加急性肝衰竭长期预后转归的等级分析：同病不同结局

董金玲; 陈煜

doi:10.3969/j.issn.1001-5256.2021.09.006

慢加急性肝衰竭长期预后转归的等级分析：同病不同结局

DOI: 10.3969/j.issn.1001-5256.2021.09.006

董金玲^{1, 2},
陈煜^{1, 2, ,}

1.
首都医科大学附属北京佑安医院肝病中心四科，北京 100069
2.
肝衰竭与人工肝治疗研究北京市重点实验室，北京 100069

基金项目:

国家科技重大专项 (2017ZX10203201-005);

国家科技重大专项 (2017ZX10203201-007);

国家重点研发计划 (2017YFA0103000)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：董金玲负责资料分析，撰写文章，修改论文；陈煜负责课题设计，拟定写作思路，指导文章撰写并最后定稿。

详细信息

通信作者:
陈煜，chybeyond1071@ccmu.edu.cn

中图分类号: R575.3
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- 被引次数: 0
出版历程
- 收稿日期: 2021-02-19
- 录用日期: 2021-04-16
- 出版日期: 2021-09-20

Prognostic grade of acute-on-chronic liver failure: Different outcomes of the same disease

Jinling DONG^{1, 2},
Yu CHEN^{1, 2
, ,}

1.
Fourth Department of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
2.
Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China

Research funding:

Major Projects of National Science and Technology (2017ZX10203201-005);

Major Projects of National Science and Technology (2017ZX10203201-007);

National Key Research and Development Plan Funding (2017YFA0103000)

摘要

摘要: 慢加急性肝衰竭(ACLF)是在慢性肝病基础上发生的急性肝功能失代偿，伴随着器官功能衰竭和短期高死亡率为特点的复杂临床综合征。ACLF病程有长有短，疾病具有可逆转性，患者长期预后转归结局多样化，临床医生应尽早准确评估患者的预后，以优化治疗方案，提高患者生存率。就ACLF患者预后长期转归首次进行5个等级的描述：Ⅰ级为理想的结局：无肝硬化；Ⅱ级为满意的结局：代偿性肝硬化，表现为可逆转的肝硬化或持续代偿性的肝硬化；Ⅲ级为可接受的结局：失代偿性肝硬化，表现为失代偿性肝硬化或慢性肝衰竭；Ⅳ级为移植后存活结局；Ⅴ级为死亡结局，以期为临床长期预后结局判断提供参考。
- 慢加急性肝衰竭 /
- 预后 /
- 结局
Abstract: Acute-on-chronic liver failure (ACLF) is a complex clinical syndrome characterized by acute liver function decompensation on the basis of chronic liver diseases, with organ failure and a high short-term mortality rate. The course of ACLF varies across patients, and the disease is reversible. Patients tend to have diverse long-term outcomes, and clinicians should evaluate the prognosis of patients as early as possible to optimize treatment regimen and improve survival rate. This article describes the following five grades of the long-term prognosis of patients with ACLF for the first time: grade Ⅰ is the ideal outcome of no cirrhosis; grade Ⅱ is the satisfactory outcome of compensated liver cirrhosis manifesting as reversible liver cirrhosis or persistent compensated liver cirrhosis; grade Ⅲ is the acceptable outcome of decompensated liver cirrhosis manifesting as decompensated liver cirrhosis or chronic liver failure; grade Ⅳ is the outcome of survival after transplantation; grade Ⅴ is the outcome of death. This article aims to provide a reference for judging long-term clinical prognosis.
- Acute-On-Chronic Liver Failure /
- Prognosis /
- Outcome

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参考文献(11)

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