Expert consensus on perioperative vascular complications for liver transplantation(2021)
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摘要: 肝移植术后血管并发症是造成移植肝功能障碍和移植物丢失的重要原因之一,发生率为5%~25%,病死率高。供受者复杂多变的血管条件、吻合技术、感染和移植后急慢性排斥反应等,均可引起肝移植血管并发症。血管并发症的类型多元、复杂,按血管构造可分为动脉并发症和静脉并发症;按血流特征可分为流入道(肝动脉、门静脉)障碍或流出道(肝静脉、腔静脉)障碍;按病变性质可分为破裂出血、狭窄、血栓形成及假性动脉瘤等;按发生时段可分为早期和晚期。手术方案设计与外科操作技术等,是治疗肝移植术后早期血管并发症的技术因素;而血管并发症的类型及其伴随的临床表现与诊治策略的选择及临床转归密切相关。因此,中华医学会器官移植学分会围手术期管理学组特制定《肝移植围手术期血管并发症诊治专家共识(2021版)》,旨在规范与优化肝移植受者围手术期常见血管并发症的临床诊治。Abstract: Vascular complications after liver transplantation are important causes of liver dysfunction and graft loss.The incidence rate range is from 5% to 25%, and the mortality rate is high. The complex and changeable vascular conditions of the donor and recipient, anastomosis techniques, infection, and acute and chronic rejection after transplantation can all cause vascular complications of liver transplantation. The types of vascular complications are diverse and complex. According to the vascular structure, they can be divided into arterial and venous complications; according to the characteristics of blood flow, they can be divided into inflow tract (hepatic artery, portal vein) or outflow tract (hepatic vein, vena cava) disorders; according to the nature of the lesion, they can be divided into rupture, stenosis, thrombosis and pseudoaneurysm, etc; according to the time of occurrence, they can be divided into early or late. Surgical plan design and surgical operation techniques are the technical factors of early vascular complications after liver transplantation. The types of vascular complications and their accompanying clinical manifestations are closely related to the choice of diagnosis and treatment strategies and clinical outcomes. Therefore, the Perioperative Management Group of Chinese Society of Organ Transplantation of Chinese Medical Association formulated the Expert Consensus on Diagnosis and Treatment of Perioperative Vascular Complications of Liver Transplantation, aiming to standardize and optimize the clinical diagnosis and treatment of common perioperative vascular complications in liver transplant recipients.
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[1] NETO JS, FONSECA EA, VINCENZI R, et al. Technical choices in pediatric living donor liver transplantation: The path to reduce vascular complications and improve survival[J]. Liver Transpl, 2020, 26(12): 1644-1651. DOI: 10.1002/lt.25875. [2] ZHONG J, SMITH C, WALKER P, et al. Imaging post liver transplantation part Ⅰ: Vascular complications[J]. Clin Radiol, 2020, 75(11): 845-853. DOI: 10.1016/j.crad.2020.06.007. [3] JU WQ, HE XS, GUO ZY, et al. Diagnosis and treatment of early-stage hepatic artery thrombosis after adult liver transplantation[J]. Chin J Hepatobiliary Surg, 2012, 18(1): 19-22. DOI: 10.3760/cma.j.issn.1007-8118.2012.01.006.鞠卫强, 何晓顺, 郭志勇, 等. 成人肝移植术后早期肝动脉血栓形成的诊断与治疗[J]. 中华肝胆外科杂志, 2012, 18(1): 19-22. DOI: 10.3760/cma.j.issn.1007-8118.2012.01.006. [4] HEATON ND. Hepatic artery thrombosis: Conservative management or retransplantation?[J]. Liver Transpl, 2013, 19(Suppl 2): s14-s16. DOI: 10.1002/lt.23739. [5] DELGADO-MORALEDA JJ, BALLESTER-VALLÉS C, MARTI-BONMATI L. Role of imaging in the evaluation of vascular complications after liver transplantation[J]. Insights Imaging, 2019, 10(1): 78. DOI: 10.1186/s13244-019-0759-x. [6] FRONGILLO F, LIROSI MC, NURE E, et al. Diagnosis and management of hepatic artery complications after liver transplantation[J]. Transplant Proc, 2015, 47(7): 2150-2155. DOI: 10.1016/j.transproceed.2014.11.068. [7] PAWLAK J, GRODZICKI M, LEOWSKA E, et al. Vascular complications after liver transplantation[J]. Transplant Proc, 2003, 35(6): 2313-2315. DOI: 10.1016/s0041-1345(03)00836-4. [8] GAO HJ, CHEN G, WANG H, et al. Cover-stent and embolization treatment of hepatic artery pseudoaneurysm following liver transplantation[J]. Chin J Hepatobiliary Surg, 2014, 20(1): 29-31. DOI: 10.3760/cma.j.issn.1007-8118.2014.01.008.高海军, 陈光, 王浩, 等. 栓塞和支架治疗肝移植术后肝动脉假性动脉瘤[J]. 中华肝胆外科杂志, 2014, 20(1): 29-31. DOI: 10.3760/cma.j.issn.1007-8118.2014.01.008. [9] GRIMALDI C, DI FRANCESCO F, CHIUSOLO F, et al. Aggressive prevention and preemptive management of vascular complications after pediatric liver transplantation: A major impact on graft survival and long-term outcome[J]. Pediatr Transplant, 2018, 22(8): e13288. DOI: 10.1111/petr.13288. [10] SAAD WE. Nonocclusive hepatic artery hypoperfusion syndrome (splenic steal syndrome) in liver transplant recipients[J]. Semin Intervent Radiol, 2012, 29(2): 140-146. DOI: 10.1055/s-0032-1312576. [11] WOJCICKI M, PAKOSZ-GOLANOWSKA M, LUBIKOWSKI J, et al. Direct pressure measurement in the hepatic artery during liver transplantation: Can it prevent the "steal" syndrome?[J]. Clin Transplant, 2012, 26(2): 223-228. DOI: 10.1111/j.1399-0012.2011.01478.x. [12] GRIESER C, DENECKE T, STEFFEN IG, et al. Multidetector computed tomography for preoperative assessment of hepatic vasculature and prediction of splenic artery steal syndrome in patients with liver cirrhosis before transplantation[J]. Eur Radiol, 2010, 20(1): 108-117. DOI: 10.1007/s00330-009-1535-y. [13] ZOU WL, ZHANG W, REN XY, et al. Diagnosis, prophylaxis and treatment of splenic arterial steal syndrome after orthotopic liver transplantation[J]. Chin J Hepatobiliary Surg, 2015, 21(6): 382-387. DOI: 10.3760/cma.j.issn.1007-8118.2015.06.006.邹卫龙, 张薇, 任秀昀, 等. 肝移植术后脾动脉盗血综合征的诊断和防治[J]. 中华肝胆外科杂志, 2015, 21(6): 382-387. DOI: 10.3760/cma.j.issn.1007-8118.2015.06.006. [14] DOKMAK S, AUSSILHOU B, BELGHITI J. Liver transplantation and splenic artery steal syndrome: The diagnosis should be established preoperatively[J]. Liver Transpl, 2013, 19(6): 667-668. DOI: 10.1002/lt.23639. [15] GARCÍA-CRIADO A, GILABERT R, BIANCHI L, et al. Impact of contrast-enhanced ultrasound in the study of hepatic artery hypoperfusion shortly after liver transplantation: Contribution to the diagnosis of artery steal syndrome[J]. Eur Radiol, 2015, 25(1): 196-202. DOI: 10.1007/s00330-014-3377-5. [16] RATHER SA, NAYEEM MA, AGARWAL S, et al. Vascular complications in living donor liver transplantation at a high-volume center: Evolving protocols and trends observed over 10 years[J]. Liver Transpl, 2017, 23(4): 457-464. DOI: 10.1002/lt.24682. [17] CHEN WZ, ZHANG SN, ZHONG YM, et al. Percutaneous intravascular interventional treatment of portal venous complications after liver transplantation[J]. J Imag Res Med Appl, 2020, 4(13): 34-37. DOI: 10.3969/j.issn.2096-3807.2020.13.017.陈文忠, 张升宁, 钟粤明, 等. 肝移植术后门静脉系统并发症的血管内介入治疗[J]. 影像研究与医学应用, 2020, 4(13): 34-37. DOI: 10.3969/j.issn.2096-3807.2020.13.017. [18] VÄLI T, TEIN A, TIGANIK V, et al. Vascular complications after orthotopic liver transplantation in Estonia[J]. Transplant Proc, 2013, 45(3): 1201-1203. DOI: 10.1016/j.transproceed.2012.10.011. [19] KHOSLA A, FETZER D, REIS S, et al. Vascular complications following liver transplantation: Diagnosis and intervention[J]. Contemporary Diagnostic Radiology, 2016, 39(26): 1-6. DOI: 10.1097/01.CDR.0000510765.59561.51. [20] FAN L, ZHANG QY, XIONG Y, et al. Progress of digital subtraction angiography in treatment of vascular complications after liver transplantation[J]. Chin J Hepatobiliary Surg, 2015, 21(1): 63-67. DOI: 10.3760/cma.j.issn.1007-8118.2015.01.020.范林, 张秋艳, 熊艳, 等. 肝移植术后血管并发症介入治疗的进展[J]. 中华肝胆外科杂志, 2015, 21(1): 63-67. DOI: 10.3760/cma.j.issn.1007-8118.2015.01.020.
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