亲属活体肝移植治疗儿童Caroli病1例报告

赵宇翔; 贾磊; 李海洋

doi:10.3969/j.issn.1001-5256.2021.09.037

亲属活体肝移植治疗儿童Caroli病1例报告

DOI: 10.3969/j.issn.1001-5256.2021.09.037

赵宇翔¹,
贾磊^2a,
李海洋^2b, ,

1.
贵州医科大学临床医学院，贵阳 550004
2a.
贵州医科大学附属医院移植科，贵阳 550004
2b.
贵州医科大学附属医院肝胆外科，贵阳 550004

基金项目:

贵州省科学技术基金 (QKHJC 〔2019〕 No. 1267)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：赵宇翔、贾磊负责拟定写作思路，收集数据，资料分析，撰写论文；李海洋参与课题设计，指导撰写文章，修改论文并最后定稿。

详细信息

通信作者:
李海洋，2690527939@qq.com

中图分类号: R657.44;R617
计量
- 文章访问数: 550
- HTML全文浏览量: 209
- PDF下载量: 32
- 被引次数: 0
出版历程
- 收稿日期: 2021-01-14
- 录用日期: 2021-02-10
- 出版日期: 2021-09-20

Living-related donor liver transplantation for pediatric patients with Caroli disease: A case report

Yuxiang ZHAO¹,
Lei JIA^2a,
Haiyang LI^{2b
, ,}

1.
School of Clinical Medicine, Guizhou Medical University, Guiyang 550004, China
2a.
Department of Transplantation, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
2b.
Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

Research funding:

Science and Technology Fund of Guizhou Province (QKHJC 〔2019〕 No. 1267)

摘要

- Caroli病 /
- 肝移植 /
- 治疗学
- Caroli Disease /
- Liver Transplantation /
- Therapeutics

HTML全文

图 1 腹部增强CT

注：a、b，腹部增强CT提示肝内多发胆管囊状扩张；c，箭头所示为扩张的脾动脉。

下载: 全尺寸图片幻灯片

图 2 病理检查结果(HE染色)

注：a，肝小叶结构紊乱，可见纤维组织增生，内见胆管扩张增生(×100)；b，扩张的胆管内可见淤胆，周围可见中性粒细胞浸润(×200)。

下载: 全尺寸图片幻灯片

参考文献(22)

[1]	HAN X, DING XL, LI XM, et al. Gastrointestinal bleeding induced by Caroli disease: A case report[J]. J Clin Hepatol, 2020, 36(1): 169-170. DOI: 10.3969/j.issn.1001-5256.2020.01.039. 韩西, 丁晓玲, 李雪梅, 等. Caroli病引发上消化道出血1例报告[J]. 临床肝胆病杂志, 2020, 36(1): 169-170. DOI: 10.3969/j.issn.1001-5256.2020.01.039.
[2]	WEHRMAN A, KRIEGERMEIER A, WEN J. Diagnosis and management of hepatobiliary complications in autosomal recessive polycystic kidney disease[J]. Front Pediatr, 2017, 5: 124. DOI: 10.3389/fped.2017.00124.
[3]	MAVLIKEEV M, TITOVA A, SAITBURKHANOVA R, et al. Caroli syndrome: A clinical case with detailed histopathological analysis[J]. Clin J Gastroenterol, 2019, 12(2): 106-111. DOI: 10.1007/s12328-018-0917-6.
[4]	LI J, LIU LW, LUO J, et al. Clinicopathological features of Caroli disease/Caroli syndrome: An analysis of 21 cases[J]. Natl Med J China, 2020, 100(38): 3005-3009. DOI: 10.3760/cma.j.cn112137-20200630-01995. 李娟, 刘立伟, 罗娟, 等. Caroli病或Caroli综合征患者21例临床病理特征分析[J]. 中华医学杂志, 2020, 100(38): 3005-3009. DOI: 10.3760/cma.j.cn112137-20200630-01995.
[5]	KUMAR A, AKSELROD D, PRIKIS M. Caroli disease revisited: A case of a kidney transplant patient with autosomal polycystic kidney disease and recurrent episodes of cholangitis[J]. Transplant Proc, 2019, 51(2): 541-544. DOI: 10.1016/j.transproceed.2018.12.025.
[6]	FAHRNER R, DENNLER SG, INDERBITZIN D. Risk of malignancy in Caroli disease and syndrome: A systematic review[J]. World J Gastroenterol, 2020, 26(31): 4718-4728. DOI: 10.3748/wjg.v26.i31.4718.
[7]	Section of Biliary Surgery, Branch of Surgery, Chinese Medical Association. Guideline for the diagnosis and treatment for biliary dilatation (2017 edition)[J]. Chin J Dig Surg, 2017, 16(8): 767-774. DOI: 10.3760/cma.j.issn.1673-9752.2017.08.001. 中华医学会外科学分会胆道外科学组. 胆管扩张症诊断与治疗指南(2017版)[J]. 中华消化外科杂志, 2017, 16(8): 767-774. DOI: 10.3760/cma.j.issn.1673-9752.2017.08.001.
[8]	SHI W, HUANG XM, FENG YL, et al. Factors contributing to diagnostic delay of Caroli syndrome: A single-center, retrospective study[J]. BMC Gastroenterol, 2020, 20(1): 317. DOI: 10.1186/s12876-020-01442-5.
[9]	MOSLIM MA, GUNASEKARAN G, VOGT D, et al. Surgical management of Caroli's disease: Single center experience and review of the literature[J]. J Gastrointest Surg, 2015, 19(11): 2019-2027. DOI: 10.1007/s11605-015-2918-9.
[10]	FAHRNER R, DENNLER S, DONDORF F, et al. Liver resection and transplantation in Caroli disease and syndrome[J]. J Visc Surg, 2019, 156(2): 91-95. DOI: 10.1016/j.jviscsurg.2018.06.001.
[11]	ROMINE MM, WHITE J. Role of transplant in biliary disease[J]. Surg Clin North Am, 2019, 99(2): 387-401. DOI: 10.1016/j.suc.2018.12.009.
[12]	HARRING TR, NGUYEN NT, LIU H, et al. Caroli disease patients have excellent survival after liver transplant[J]. J Surg Res, 2012, 177(2): 365-372. DOI: 10.1016/j.jss.2012.04.022.
[13]	MILLWALA F, SEGEV DL, THULUVATH PJ. Caroli's disease and outcomes after liver transplantation[J]. Liver Transpl, 2008, 14(1): 11-17. DOI: 10.1002/lt.21366.
[14]	TENG DH, WU D, ZHANG W, et al. Liver transplantation in the treatment of Caroli syndrome: A single- center experience[J]. Chin J Surg, 2020, 58(12): 956-958. DOI: 10.3760/cma.j.cn112139-20200507-00364. 滕大洪, 吴迪, 张威, 等. 肝移植治疗Caroli综合征单中心经验[J]. 中华外科杂志, 2020, 58(12): 956-958. DOI: 10.3760/cma.j.cn112139-20200507-00364.
[15]	KHAN K, SCHWARZENBERG SJ, SHARP HL, et al. Morbidity from congenital hepatic fibrosis after renal transplantation for autosomal recessive polycystic kidney disease[J]. Am J Transplant, 2002, 2(4): 360-365. DOI: 10.1034/j.1600-6143.2002.20412.x.
[16]	CHAPAL M, DEBOUT A, DUFAY A, et al. Kidney and liver transplantation in patients with autosomal recessive polycystic kidney disease: A multicentric study[J]. Nephrol Dial Transplant, 2012, 27(5): 2083-2088. DOI: 10.1093/ndt/gfr588.
[17]	Chinese Society of Organ Transplantation, Chinese Medical Association. Technical specification for pediatric liver transplantation in China (2019 edition)[J/CD]. Chin J Transplant (Electronic Edition), 2019, 13(3): 181-186. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.005. 中华医学会器官移植学分会. 中国儿童肝移植操作规范(2019版)[J/CD]. 中华移植杂志(电子版), 2019, 13(3): 181-186. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.005.
[18]	LYU GY. Advancement and prospect of living donor liver transplantation (2000-2020)[J]. Chin J Pract Surg, 2020, 40(2): 163-166, 170. DOI: 10.19538/j.cjps.issn1005-2208.2020.02.06. 吕国悦. 活体肝移植进展与展望(2000-2020)[J]. 中国实用外科杂志, 2020, 40(2): 163-166, 170. DOI: 10.19538/j.cjps.issn1005-2208.2020.02.06.
[19]	YU HL, YU WL, WENG YQ, et al. Changes in levels of brain injury markers in serum during perioperative period in infants underwent parent liver transplantation and their clinical significances[J]. J Jilin Univ (Med Edit), 2021, 47(1): 168-172. DOI: 10.13481/j.1671-587X.20210123. 于洪丽, 喻文立, 翁亦齐, 等. 亲体肝移植患儿围术期血清中脑损伤标志物水平的变化及临床意义[J]. 吉林大学学报(医学版), 2021, 47(1): 168-172. DOI: 10.13481/j.1671-587X.20210123.
[20]	GU GX, ZONG ZP, ZHOU T, et al. Living related donor liver transplantation for infant with Crigler-Najjar syndrome type Ⅰ: A report of one case and literature review[J]. Ogran Transplantation, 2020, 11(4): 471-476. DOI: 10.3969/j.issn.1674-7445.2020.04.008. 顾广祥, 宗志鹏, 周韬, 等. 亲属活体肝移植治疗婴儿Crigler-Najjar综合征Ⅰ型1例并文献复习[J]. 器官移植, 2020, 11(4): 471-476. DOI: 10.3969/j.issn.1674-7445.2020.04.008.
[21]	LAI Q, LERUT J. Proposal for an algorithm for liver transplantation in Caroli's disease and syndrome: Putting an uncommon effort into a common task[J]. Clin Transplant, 2016, 30(1): 3-9. DOI: 10.1111/ctr.12640.
[22]	GAO W, WANG K, MA N, et al. Living donor liver transplantations for pediatric patients withbiliary atresia in a single center: 306 cases report[J]. Chin J Organ Transplant, 2019, 40(1): 13-17. DOI: 10.3760/cma.j.issn.0254-1785.2019.01.004. 高伟, 王凯, 马楠, 等. 亲属活体肝移植治疗儿童胆道闭锁306例临床分析[J]. 中华器官移植杂志, 2019, 40(1): 13-17. DOI: 10.3760/cma.j.issn.0254-1785.2019.01.004.