HBV及其相关蛋白泛素化修饰研究进展

涂文辉; 刘锦; 朱传武

doi:10.3969/j.issn.1001-5256.2021.09.038

HBV及其相关蛋白泛素化修饰研究进展

DOI: 10.3969/j.issn.1001-5256.2021.09.038

涂文辉^{1, 2},
刘锦¹,
朱传武^1, ,

1.
苏州大学附属传染病医院，苏州市第五人民医院肝病科，江苏苏州 215131
2.
浙江省台州市立医院感染科, 浙江台州 318000

基金项目:

浙江省医药卫生科技计划项目 (2020KY368);

浙江省医药卫生科技计划项目 (2021KY1217);

苏州市姑苏卫生人才计划项目 (GSWS2020091)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：涂文辉、刘锦负责文献查找，资料分析，撰写论文；朱传武拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
朱传武，zhuchw@126.com

中图分类号: R512.62
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- 文章访问数: 466
- HTML全文浏览量: 318
- PDF下载量: 60
- 被引次数: 0
出版历程
- 收稿日期: 2021-01-16
- 录用日期: 2021-02-23
- 出版日期: 2021-09-20

Research advances in hepatitis B virus and ubiquitination of related proteins

Wenhui TU^{1, 2},
Jin LIU¹,
Chuanwu ZHU^{1
, ,}

1.
Department of Hepatology, The Affiliated Infectious Diseases Hospital of Soochow University & The Fifth People's Hospital of Suzhou, Suzhou, Jiangsu 215131, China
2.
Department of Infectious Diseases, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China

Research funding:

Projects of Medical and Health Technology in Zhejiang Province (2020KY368);

Projects of Medical and Health Technology in Zhejiang Province (2021KY1217);

Project of Gusu Health Talent Plan of Suzhou (GSWS2020091)

摘要

摘要: 蛋白质泛素化广泛存在于细胞内，是蛋白翻译后的一种修饰。HBV及其相关蛋白的泛素化研究越来越受到重视。对HBV及其相关蛋白的泛素化修饰进行了综述，为进一步了解HBV的复制调控及其蛋白的泛素化研究提供了借鉴，为治愈慢性HBV感染提供新的思路和方法。
- 乙型肝炎病毒 /
- 病毒蛋白质类 /
- 泛素化
Abstract: Protein ubiquitination is widely observed in cells and is a modification after protein translation. Hepatitis B virus (HBV) and ubiquitination of related proteins have attracted more and more attention. This article reviews HBV and the ubiquitination of related proteins, so as to provide a reference for further research on the regulation of HBV replication and the ubiquitination of related proteins, as well as new ideas and methods for curing chronic HBV infection.
- Hepatitis B Virus /
- Viral Proteins /
- Ubiquitination

HTML全文

图 1 E3泛素连接酶调节抗病毒天然免疫信号

下载: 全尺寸图片幻灯片

图 2 HBx介导的发病机制中与泛素蛋白酶体系统有关的情况

下载: 全尺寸图片幻灯片

图 3 泛素蛋白酶体系统在HBV复制中的调控机制

下载: 全尺寸图片幻灯片

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