宏基因组学测序技术在肝硬化脓毒症中的应用

贝小歌; 陈金军; 黎倍伶

doi:10.3969/j.issn.1001-5256.2021.09.041

宏基因组学测序技术在肝硬化脓毒症中的应用

DOI: 10.3969/j.issn.1001-5256.2021.09.041

南方医科大学南方医院肝病中心，广州 510515

基金项目:

国家科技部重大专项 (2018ZX10723203);

国家科技部重大专项 (2018ZX10302206);

国家重点研发计划 (2017YFC0908100);

广东省珠江人才计划 (2017BT01S131);

南方医院"临床研究专项" (2018CR037);

南方医院"临床研究专项" (2020CR026);

南方医科大学临床启动计划 (LC2019ZD006)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：贝小歌负责拟定写作思路，撰写论文；陈金军、黎倍伶参与修改论文，指导撰写文章并最后定稿。

详细信息

通信作者:
陈金军，chjj@smu.edu.cn

黎倍伶，lbling123@163.com

中图分类号: R575.2
计量
- 文章访问数: 623
- HTML全文浏览量: 226
- PDF下载量: 49
- 被引次数: 0
出版历程
- 收稿日期: 2021-02-03
- 录用日期: 2021-05-07
- 出版日期: 2021-09-20

Application of metagenomic next-generation sequencing in sepsis in liver cirrhosis

Liver Disease Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Research funding:

National Science and Technology Major Project (2018ZX10723203);

National Science and Technology Major Project (2018ZX10302206);

National Key Research and Development Program of China (2017YFC0908100);

Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01S131);

Clinical Research Program of Nanfang Hospital (2018CR037);

Clinical Research Program of Nanfang Hospital (2020CR026);

Clinical Research Program of Nanfang Hospital, Southern Medical University (LC2019ZD006)

摘要

摘要: 肝硬化患者由于持续的全身性炎症和免疫抑制状态，容易发生细菌感染，严重时可进展为脓毒症。早期有效的抗生素治疗是改善脓毒症患者预后的关键。简述了肝硬化患者发生脓毒症的病理生理机制及诊疗现状。认为宏基因组学测序技术可用于指导脓毒症的有效抗菌治疗。
- 肝硬化 /
- 脓毒症 /
- 宏基因组学 /
- 序列分析
Abstract: Due to persistent systemic inflammation and immunosuppressive conditions, patients with liver cirrhosis are susceptible to bacterial infection, which may progress to sepsis without proper control. Early effective antibiotic therapy is the key to improving the prognosis of patients with sepsis. This article briefly describes the pathophysiological mechanism of sepsis in patients with liver cirrhosis and the current status of the diagnosis and treatment of sepsis, and it is pointed out that metagenomic next-generation sequencing can be used to guide effective antibacterial treatment of sepsis.
- Liver Cirrhosis /
- Sepsis /
- Metagenomics /
- Sequence Analysis

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