昼夜节律及其相关基因与非酒精性脂肪性肝病的关系

赵晨露; 赵文霞

doi:10.3969/j.issn.1001-5256.2021.09.045

昼夜节律及其相关基因与非酒精性脂肪性肝病的关系

DOI: 10.3969/j.issn.1001-5256.2021.09.045

赵晨露¹,
赵文霞^2, ,

1.
河南中医药大学第一临床医学院, 郑州 450016
2.
河南中医药大学第一附属医院脾胃肝胆科, 郑州 450000

基金项目:

国家自然科学基金面上项目 (81473651);

河南省特色骨干学科中医学学科建设项目 (STG-ZYXKY-2020024)

利益冲突声明: 所有作者均声明不存在利益冲突。

作者贡献声明: 赵晨露负责撰写论文；赵文霞负责指导撰写文章、修改论文。

详细信息

通信作者:
赵文霞, Zhao-wenxia@163.com

中图分类号: R575.5
计量
- 文章访问数: 656
- HTML全文浏览量: 164
- PDF下载量: 61
- 被引次数: 0
出版历程
- 收稿日期: 2021-01-21
- 录用日期: 2021-02-20
- 出版日期: 2021-09-20

Association of circadian rhythm and related genes with nonalcoholic fatty liver disease

Chenlu ZHAO¹,
Wenxia ZHAO^{2
, ,}

1.
The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450016, China
2.
Department of Hepatology and Splee-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

General Project of National Natural Science Foundation of China (81473651);

Project of Characteristic Traditional Chinese Medicine Discipline Construction of Henan Province (STG-ZYXKY-2020024)

摘要

摘要: 近年来昼夜节律与代谢性疾病的关系逐渐受到人们重视。大量临床研究表明, 经常熬夜、轮班的人群非酒精性脂肪性肝病的发生风险明显高于作息规律的人群。基于现有数据, 重点从脂质代谢、葡萄糖代谢、肠道菌群、氧化应激、内质网应激五个方面总结了昼夜节律基因在非酒精性脂肪性肝病中的作用机制。
- 昼夜节律 /
- 基因 /
- 非酒精性脂肪性肝病
Abstract: The association between circadian rhythm and metabolic diseases has attracted more and more attention in recent years. A large number of clinical studies have shown that people who often stay up late or work in shifts have a significantly higher risk of nonalcoholic fatty liver disease than those with regular work and rest. Based on current research findings, this article reviews the mechanism of action of circadian rhythm genes in nonalcoholic fatty liver disease from the five aspects of lipid metabolism, glucose metabolism, intestinal flora, oxidative stress, and endoplasmic reticulum stress.
- Circadian Rhythm /
- Gene /
- Non-alcoholic Fatty Liver Disease

HTML全文

图 1 昼夜节律的分子调控机制

下载: 全尺寸图片幻灯片

表 1 不同部位昼夜节律基因BMAL1敲除或沉默对糖代谢的影响

作者(年份)	基因敲除/沉默	部位	表型
叶绿, 等(2020)	Bmal1^-沉默	胰腺	ROS、Nrf2表达增加, GSIS、CAT、GSH-Px水平升高
叶绿, 等(2020)	Bmal1^-沉默	胰腺	ROS和细胞凋亡增加, Sirt1 mRNA表达减少
Curtis AM, 等(2007)	Bmal1^-/-	全身	血压和心率昼夜节律改变
Anea CB, 等(2009)	Bmal1^-/-	全身	胆固醇和甘油三酯升高, 血管重构受损, 血管损伤和内皮功能障碍
Marcheva B, 等(2010)	Bmal1^-/-	全身	胰岛素抵抗、肥胖, 葡萄糖耐受不良, 胰岛素分泌减少
Shi S-q, 等(2013)	Bmal1^-/-	全身	葡萄糖耐受不良, 胰岛素分泌减少
Shimba S, 等(2011)	Bmal1^-/-	全身	游离脂肪酸、甘油三酯、胆固醇水平增高, 脂肪组织、肝脏、肌肉组织脂肪沉积
Sadacca LA, 等(2011)	Bmal1^-/-	胰腺	胰岛素分泌改变
Paschos GK, 等(2012)	Bmal1^-/-	脂肪组织	进食行为改变、肥胖
Xie Z, 等(2015)	Bmal1^-/-	平滑肌	胰岛细胞大小和增殖受损, 血压节律丧失
Harfmann BD, 等(2016)	Bmal1^-/-	骨骼肌	肌肉中的葡萄糖代谢受损和紊乱
Chaix A, 等(2019)	Bmal1^-/-	肝脏	血清甘油三酯升高, 肝内脂肪沉积, 循环葡萄糖清除受损
Lamia KA, 等(2008)	Bmal1^-/-	肝脏	血清甘油三酯升高, 肝内脂肪沉积, 循环葡萄糖清除受损

下载: 导出CSV

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