靶向肿瘤微环境治疗胰腺癌的新进展

张飞宇; 阿迪拉·亚克普; 赵金明; 高沿航

doi:10.3969/j.issn.1001-5256.2021.09.049

靶向肿瘤微环境治疗胰腺癌的新进展

DOI: 10.3969/j.issn.1001-5256.2021.09.049

吉林大学第一医院肝病科, 长春 130021

基金项目:

国家自然科学基金 (81972265);

吉林省自然科学基金 (20200201324JC)

利益冲突声明: 所有作者均声明不存在利益冲突。

作者贡献声明: 张飞宇负责选题, 收集分析资料, 撰写文章；阿迪拉·亚克普、赵金明参与选题, 收集资料；高沿航教授拟定写作思路, 指导撰写文章, 提供修改意见并最终定稿。

详细信息

通信作者:
高沿航, yanhang@mail.jlu.edu.cn

中图分类号: R735.9
计量
- 文章访问数: 814
- HTML全文浏览量: 253
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- 被引次数: 0
出版历程
- 收稿日期: 2021-02-23
- 录用日期: 2021-04-06
- 出版日期: 2021-09-20

New advances in the treatment of pancreatic cancer by targeting tumor microenvironment

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

National Natural Science Foundation of China (81972265);

Natural Science Foundation of Jilin Province (20200201324JC)

摘要

摘要: 胰腺癌是5年生存率最低的消化道恶性肿瘤, 现有的一线治疗方案并未明显改善患者总体预后, 因此需要探索新的治疗方式。胰腺癌肿瘤微环境如基质屏障、免疫微环境、外泌体在促进胰腺癌细胞增殖、浸润、转移及放化疗抵抗中起到重要作用。总结了与胰腺癌肿瘤微环境相关的潜在靶点及其临床进展, 以期为胰腺癌治疗提供新思考。
- 胰腺肿瘤 /
- 肿瘤微环境 /
- 免疫疗法
Abstract: Pancreatic cancer is the malignant tumor of the digestive tract with the lowest 5-year survival rate, and current first-line treatment regimens cannot significantly improve the overall prognosis of patients, so it is necessary to explore new treatment methods. A large number of studies have shown that the tumor microenvironment of pancreatic cancer, such as stromal barrier, immune microenvironment, and exosomes, plays an important role in promoting the proliferation, invasion, metastasis, and chemoradiotherapy resistance of pancreatic cancer cells. This article summarizes the potential targets associated with the tumor microenvironment of pancreatic cancer and related clinical research advances, in order to provide new ideas for the treatment of pancreatic cancer.
- Pancreatic Neoplasms /
- Tumor Microenvironment /
- Immunotherapy

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参考文献(24)

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