促红细胞生成素产生肝细胞受体在肝纤维化、肝癌发病机制中的作用

童伟钊; 刘伟; 胡国信

doi:10.3969/j.issn.1001-5256.2021.11.038

促红细胞生成素产生肝细胞受体在肝纤维化、肝癌发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2021.11.038

童伟钊^{1, 2},
刘伟³,
胡国信^1, ,

1.
北京大学深圳医院感染性疾病科，广东深圳 518036
2.
汕头大学医学院，广东汕头 515041
3.
深圳北京大学香港科技大学医学中心生物医学研究所，深圳市神经结构生物学重点实验室，广东深圳 518036

基金项目:

国家自然科学基金 (81473473)

详细信息

通信作者:
胡国信，huguoxin8228@sina.com

中图分类号: R575.2;R735.7
计量
- 文章访问数: 692
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- PDF下载量: 47
- 被引次数: 0
出版历程
- 收稿日期: 2021-07-30
- 录用日期: 2021-08-31
- 出版日期: 2021-11-20

Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

Weizhao TONG^{1, 2},
wei LIU³,
Guoxin HU^{1
, ,}

1.
Department of Infectious Diseases, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
2.
Shantou University Medical College, Shantou, Guangdong 515041, China
3.
Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center; Shenzhen Key Laboratory for Neuronal Structural Biology, Shenzhen 518036, China

Research funding:

National Natural Science Foundation of China (81473473)

摘要

摘要: 促红细胞生成素产生肝细胞(Eph)受体是受体酪氨酸激酶家族中最大的亚族，参与机体胚胎发育、血管生成、轴突导向等生理过程。近来有研究显示，Eph受体过量表达于肝纤维化及肝癌组织中，并在肝癌的生长、侵袭、转移中发挥重要作用。探讨了Eph受体在肝纤维化及肝细胞癌中的作用机制，提示Eph受体可能是肝纤维化、肝癌发生发展过程中的重要分子。
- 促红细胞产生肝细胞受体 /
- 肝硬化 /
- 癌, 肝细胞
Abstract: Erythropoietin-producing hepatocyte (Eph) receptors are the largest subgroup of the receptor tyrosine kinase family and are involved in the physiological processes such as embryonic development, angiogenesis, and axon guidance. Recent studies have shown that Eph receptors are overexpressed in liver fibrosis and hepatocellular carcinoma tissues and play an important role in the growth, invasion, and metastasis of hepatocellular carcinoma. This article explores the mechanism of action of Eph receptors in liver fibrosis and hepatocellular carcinoma and points out that Eph receptors may be important molecules in the development and progression of liver fibrosis and hepatocellular carcinoma.
- Erythropoietin Producing Hepatocyte Receptor /
- Liver Cirrhosis /
- Carcinoma, Hepatocellular

HTML全文

图 1 Eph/Ephrin结构特点及双向信号通路

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图 2 Eph受体在肝纤维化、HCC中的作用机制

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